SR9009 High Quality CAS:1379686-30-2

Description

Stenabolic SR9009 is a compound that was developed by researchers in a bid to treat or manage medical conditions.

Stenabolic is a REV-ERB (specifically a REV-ERBα agonist) which means it impacts the metabolism, including the circadian rhythm. It's pretty complicated to explain, but here's our best layman's version:

Your body's circadian rhythm is a pattern your system cycles through every 24 hours. Experts think it is linked to sunrise and sunset. It governs things like sleep, waking, energy levels, and hunger.

Part of the cycle that keeps your circadian rhythm going involves "switching" genes on and off throughout the 24-hour cycle.

Clinical Data

History of SR-9009

Stenabolic was initially developed for its effects on the circadian rhythm and was found to improve mood, control anxiety, reduce inflammation, and even have a positive impact on weight gain. Sounds good for bodybuilding, right?

Stenabolic was also found to increase the activity of REV-ERB nuclear hormone receptors, and this boosts the bioavailability of nutrients in your body. For us as bodybuilders, this means better nutrient uptake and more of the nutrients we eat gets to our muscle tissue.

One thing you must consider about SR9009 is that there is no human research on it. There's plenty of research from animal studies (especially mice studies) but none on human subjects.

There is plenty of anecdotal evidence and feedback from guys who use it to augment their training. So be sure to go into this with your eyes open and full awareness of the lack of human research.

How Does Stenabolic SR9009 Work?

The processes behind SR9009 are pretty complicated and well beyond a short article here. If you're the deep-dive research kind of reader, take a look at this paper published in Nature Reviews Drug Discovery in 2014 or this 2016 paper published in the International Journal of Molecular Sciences.

SR9009 has a significant impact on REV-ERBA, which impacts circadian control and has knock-on effects on the immune system, sleeping patterns, energy production, and general activity.

Activation of Rev-ErbA-α by SR9009 increases exercise capacity by increasing mitochondria counts in skeletal muscle.

REV-ERB is particularly influential in the tissues of the muscles, body fat, and liver. This suggests it could help boost fat burning, "switching off" the genes which store fat and increasing the number of mitochondria in the muscles.

Mechanism of Action

All the effects observed for SR9009 derive from REV-ERB (NR1D1, NR1D2) activation in the body.

REV-ERB affects the circadian behavior of mice, altering their activity and sleep patterns [4].

Besides its effect on the circadian rhythm (suppression of BMAL1 production), REV-ERB affects many other functions related to energy production [4, 5].

REV-ERB is mainly found in liver, muscle, and fat tissue:

Liver: REV-ERB affects the rhythm of 90% of the about 900 genes under circadian control in mice liver. It turns off the genes that produce glucose without altering insulin sensitivity. It also turns on genes that generate new fat cells and reduces the inflammatory response (by affecting macrophage production) [4, 6, 7, 2].

Muscles: REV-ERB promotes the burning of fat, increases the activity of mitochondria, and promotes the generation of new while decreasing the destruction of old mitochondria [5].

Fat cells: REV-ERB turns off the genes responsible for storing fat and decreases triglyceride production [8].

In animal and cell studies, SR9009:

Increased oxygen consumption [8]

Decreased generation of new fat cells in the liver [8]

Decreased production of cholesterol and bile acids in the liver [8]

Increased the number of mitochondria in muscle [5]

Increased glucose and fatty acid use in muscle [8]

Decreased fat storage [8]

Researched Effects

1) Weight Loss

Mice injected with SR9009 for 7 days lost weight due to a decrease in fat mass. Food intake was not affected [8].

Similarly, diet-induced obese mice injected with SR9009 for 30 days lost 60% more weight than control animals. Blood levels of triglycerides, total cholesterol, free fatty acids, and insulin levels also decreased [8].

In genetically obese mice, SR9009 stopped weight gain after 12 days without affecting glucose levels or insulin tolerance [8].

2) Blood Cholesterol

SR9009 given for 7 to 10 days reduced blood levels of triglycerides and total cholesterol in mice [8].

Genetically modified mice undergoing a high cholesterol diet to obtain a fat profile similar to humans were given SR9009 for 8 weeks. Total cholesterol and triglycerides were similarly lowered, while LDL cholesterol was lowered but HDL cholesterol was unaffected [9].

3) Endurance

Mice treated with SR9009 for 30 days showed increased endurance. They ran for a longer time and covered more distance than controls [5].

SR9009 increased the number of total and active mitochondria in muscle cells (by repressing autophagy genes) [5].

4) Decreasing Inflammation

SR9009 diminished lung inflammation in rats (by reducing the production of TNF-alpha) [10].

It also reduced the production of inflammatory molecules (CCL2, MMP-9) in rat nerve cells [11].

5) Heart Disease

Genetically modified mice susceptible to hardening of the arteries were treated with SR9009 for 7 weeks. The size of the blood vessel lesions was reduced, while food intake, body weight, and blood fat levels were not affected [12].

In both normal and genetically modified old mice, SR9009 injected for 28 days improved heart function [13].

In mice with surgically induced heart growth (hypertrophy), SR9009 given for 2 weeks reduced heart size and weight, with no effect on blood pressure [13].

6) Wakefulness

As an activator of REV-ERB, S9009 changes sleep/wake patterns in mice. However, its effects are short-term and last only 12 hours [14, 15].

Mice injected with SR9009 during daytime (this is when the mice are supposed to be asleep) were more active during the day and had less deep sleep (less REM and slow-wave sleep). However, when SR9009 was injected during the night (when mice are active), it had no effect [14, 15].

SR9009 may potentially help in maintaining wakefulness when the drive for sleep is significant including shift work, jet lag, and some sleep-related disorders.

7) Anxiety

SR9009 injected twice a day for 3 to 10 days, decreased anxiety-like behavior in mice and was as effective as a benzodiazepine [14].

8) Tissue Damage (Fibrosis)

SR9009 decreased tissue damage in mice with induced liver scarring when treated with SR9009 for 2 weeks [16].

Does Stenabolic Have Side Effects?

Since Stenabolic SR9009 is a research chemical and has not been extensively studied in humans, the potential side effects are not fully known. However, some users have reported side effects such as headache, nausea, and insomnia.

Stenabolic has shown no liver toxicity.

However, we do know that SR9009 doesn't impact the body's natural hormone levels so you won't need to run a PCT if you use Stenabolic.

Is Stenabolic SR9009 legal?

Stenabolic SR9009 is not approved for human consumption, however it is legal to sell and purchase for research purposes.

Is Stenabolic SR9009 a Steroid?

Stenabolic SR9009 is not a steroid, but it is often grouped together with other performance-enhancing compounds due to its potential benefits for athletes and bodybuilders. It is important to note that using any performance-enhancing compound comes with potential risks and side effects.

Best Dosage & Cycle Length for Stenabolic

Stenabolic has a half-life of 4 hours so you'll need to split your total daily dose into 2-3 doses per day. So, if you're taking 20mg/day, take 5mg every 4 hours (say, at 8 am, 12 pm, 4 pm, 8 pm).

Start at 10mg-20mg/day (maximum) and increase only to 30mg if you need to.

Most will run Stenabolic SR9009 cycles of 8-12 weeks, followed by the same time off.

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