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Description
Viagra (sildenafil citrate) improves penile erections in men with erectile dysfunction (ED) by selectively inhibiting cGMP-specific phosphodiesterase type 5 (PDE5), which is present in all vascular tissue. It also exerts a minor inhibitory action against PDE6, which is present exclusively in rod and cone photoreceptors. At higher doses, sildenafil causes mild and transient visual symptoms in a minority of patients (mainly blue tinge to vision, increased brightness of lights). Therefore, the effects of sildenafil on the visual system have been investigated in a wide variety of clinical and preclinical studies. In preclinical studies, sildenafil shows transient reversible effects on electrical response to light. In long-term toxicology studies in which animals were exposed to high multiples of the maximum human therapeutic dose, detailed examinations have revealed no adverse effects on the structure or function of the eye. The effects of sildenafil have been systematically investigated in visual function studies in volunteers and in patients with eye disease; sildenafil does not affect visual acuity, visual fields, and contrast sensitivity. The only definite effect is transient, mild impairment of color discrimination occurring around the time of peak plasma levels. In long-term studies, no long-term effects of sildenafil on the visual system have been observed. Postmarketing, sildenafil has been prescribed to over 15 million men with ED. Isolated examples of a variety of visual adverse events have been reported. No consistent pattern has emerged to suggest any long-term effect of sildenafil on the retina or other structures of the eye. Based on this experience, intermittent, short-term, partial inhibition of PDE5 or PDE6 by sildenafil is unlikely to induce any long-term visual change.


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Clinical data
Trade names Viagra,Sildenafil,Revatio CAS
139755-83-2
Molar mass
474.6
Formula
C22H30N6O4S
Purity
Above 98%
Apprarance
White crystalline powder
Key facts
It usually takes 30 to 60 minutes for sildenafil to work for erectile dysfunction. You can take it up to 4 hours before you want to have sex.
Taking sildenafil alone will not cause an erection. You need to be sexually excited for it to work.
The most common side effects are headaches, feeling sick, indigestion and dizziness. Many people have no side effects or only mild ones.
It can be dangerous to take sildenafil if you also take medicines called nitrates (often given for chest pain). The combination can cause a dangerous fall in your blood pressure. If you're not sure if you're taking a nitrate, ask your doctor or pharmacist.
Do not drink grapefruit juice if you're taking sildenafil (Revatio) for pulmonary hypertension. It affects the way the medicine works.
Who can take sildenafil
Most men aged 18 and over can take sildenafil for erectile dysfunction.
Most adults and children aged 1 year and over can take sildenafil for pulmonary hypertension.
Who may not be able to take sildenafil
Sildenafil is not suitable for some people. To make sure it's safe for you, speak to your doctor or pharmacist before taking sildenafil if you:
have ever had an allergic reaction to sildenafil or any other medicine
are taking medicines called nitrates for chest pain (angina)
have a serious heart or liver problem
have recently had a stroke, heart attack or a heart problem – your doctor should carefully check whether your heart can take the additional strain of having sex
have low blood pressure (hypotension)
have a rare inherited eye disease, such as retinitis pigmentosa
have sickle cell anaemia (an abnormality of red blood cells), leukaemia (cancer of blood cells) or multiple myeloma (cancer of bone marrow)
have a deformity of your penis or Peyronie's disease (curved penis)
have a stomach ulcer
have a bleeding problem like haemophilia
dysfunction
Sildenafil tablets for erectile dysfunction come in different strengths ranging from 25mg to 100mg.
The usual dose is 50mg, when you need it. Do not take it more than once a day.
The dose can be increased to 100mg or decreased to 25mg depending on its effect.
Take sildenafil up to 4 hours before you want to have sex. For sildenafil to work properly, you'll need to be sexually excited.
Dosage and strength for pulmonary hypertension
Sildenafil tablets for pulmonary hypertension come in 10mg and 20mg strengths.
The usual adult dose is 20mg taken 3 times a day.
Doses for children can range from 10mg to 20mg taken 3 times a day, depending on their weight. Do not take it more than 3 times a day.
How to take tablets
Swallow tablets whole with a drink of water or juice (but not grapefruit juice).
For erectile dysfunction, it's best to take sildenafil on an empty stomach. It may take longer to work if you take it with food.
How to take liquid
If you or your child are taking sildenafil as a liquid, 1ml is usually the same as taking a 10mg tablet, but it's important to always check the medicine label.
Liquid sildenafil will usually be made up for you by your pharmacist.
The medicine will come with a plastic syringe or spoon to help you take the right amount. If you do not have a plastic syringe or spoon, ask your pharmacist for one. Do not use a kitchen teaspoon as it will not measure the right amount.
If you forget to take it
If you have pulmonary hypertension and you forget to take a dose of sildenafil, take it as soon as you remember unless it's nearly time for your next dose. In this case, just leave out the missed dose and take your next dose at the usual time.
Never take 2 doses at the same time. Never take an extra dose to make up for a forgotten one.
If you often forget doses, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine.
If you take too much
Taking too much sildenafil can cause unpleasant side effects.
Talk to your doctor if you take too much sildenafil and you're worried about any of these side effects:
headaches
dizziness
indigestion
blocked nose
changes to your vision
Packaging Options
50g / 100g
500g / 1kg
Custom packaging available
Shipping & Handling
Discreet and secure packaging
Stable international shipping
Tracking provided after dispatch
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