Peptides
BPC 157
- Description: BPC 157, a pentadecapeptide derived from human gastric juice, has been demonstrated to promote the healing of different tissues, including skin, muscle, bone, ligament and tendon in many animal studies.
- Functions: More blood vessels mean increased blood flow, nutrient supply, and removal of waste products from muscle cells, all of which are beneficial for muscle building. That said, it's vital to remember that while BPC 157 does promote muscle growth, its main role is in healing and reducing inflammation.
- Downside: Potential BPC-157 side effects typically emerge in patients who use the peptide for an extended period and in some patients with certain pre-existing conditions. The most common side effects reported by patients include: Nausea. Dizziness.
PT-141
- Description: PT-141 also known as bremelanotide is a compounded injectable prescription that can be used to improve libido. By improving libido it has been shown to increase physical arousal and genital circulation, therefore to increase the filling and function of erectile and other genital tissue in men and women.
- Half Life: The elimination half-life of bremelanotide is 2.7 hours, with a range of 1.9 to 4.0 hours. Bremelanotide is excreted 64.8% in urine and 22.8% in feces.
- Downside: A feeling of discomfort or queasiness in the stomach can be a side effect of PT-141. Most cases of nausea are mild to moderate and usually go away on their own within a few hours. Redness, itching, or pain at the injection site is a common side effect of PT-141.
- Precautions: Before using PT-141, discussing any medications or supplements, you are taking with your doctor is essential. Certain medications, such as anticoagulants and birth control pills, may interact with PT-141 and increase the risk of side effects. Additionally, alcohol not be consumed while taking PT-141.
Follistatin-344
- Description: Follistatin-344 is a recombinant human follistatin containing 344 amino acids that block myostatin and increase muscle mass.
- Benefits: These results suggest that inhibition of myostatin by FS-344, delivered by a single AAV1 injection can enhance muscle size and strength and is well tolerated for >2-years.
- Functions: It was first isolated from porcine ovarian follicular fluid in in vitro studies that identified its function as a suppressor of the release of follicle stimulating hormone (FSH).
- Downside: Follistatin blocks the action of many different proteins and hormones such as: Activins, which are involved in apoptosis, metabolism, endocrine homeostasis, bone growth, fibrosis inflammation, neurogenesis, tubulogenesis of endothelial cells, and cancer development. Myostatin, which inhibits muscle growth.
Selank
- Description: Selank has pronounced anxiolytic activity and acts as a stable neuropsychotropic, antidepressant, and antistress drug that relieves aggression and fear reaction in different animal species (Kozlovskii and Danchev, 2002; Sollertinskaya et al., 2008; Semenova et al., 2010).
- Functions: The Selank action mechanism may be related to its ability to affect the performance of the GABAergic system. Previously, it was shown that Selank causes a marked change in the expression of genes involved in inflammatory processes in the hippocampus and spleen of rodents (Kolomin et al., 2010, 2011, 2014).
- Downside: Generally, most users experience unwanted side effects within the first 2 – 4 weeks of use as the body adjusts to the supplement. These symptoms are usually classified as mild to moderate and include: Fatigue. Nausea.
IGF-1 LR3
- Description: IGF-1 LR3 builds new muscle mass by promoting nitrogen retention. It means this peptide can help your body hold onto more protein and protein synthesis which means it can help you build more muscle and repair damaged tissues.
- Functions: Increased energy levels and metabolism: By promoting the utilization of stored fats as an energy source, IGF-1 LR3 can boost your energy levels and overall metabolism. This can enhance your endurance during workouts and support a more active lifestyle.
- Instructions: There is no need to take IGF1 LR3 more than once per day with many users opting to take 2 - 3x per week. Generally, most cycles last between 4 - 6 weeks before people take a break from the substance. It's very important not to exceed a cycle of 30 - 60 days to avoid permanent side effects and long-term health risks.
- Advantage: As a result, it is approximately three times more potent than IGF-1, and possesses a significantly longer half-life of about 20–30 hours (relative to IGF-1's half-life of about 12–15 hours).
Melatonin II
- Description: Melatonin activates two high-affinity G protein-coupled receptors, termed MT1 and MT2, to exert beneficial actions in sleep and circadian abnormality, mood disorders, learning and memory, neuroprotection, drug abuse, and cancer.
- Functions: The beneficial effects of leptin and melanotan II are associated with an increase in cardiac mitochondrial oxidative metabolism and respiration, as well as with improved cardiomyocyte calcium coupling, leading to improved cardiac contractile function.
- Mechanism: If injected or used as a nasal spray, Melanotan-II can cause dramatic skin darkening in just days. The drug can also suppress appetite and lead to weight loss, another effect that some users find desirable.
- Downside: Short term side effects after administration include: Facial flushing. Reduced appetite, nausea and vomiting. In males, spontaneous erections 1-5 hours after administration (priapism), associated with yawning and stretching complex.
HGH
- Description: For adults who have a growth hormone deficiency, injections of HGH can: Increase exercise capacity. Increase bone density. Increase muscle mass.
- Functions: HGH cycles are often measured in weeks or months, and the duration can range from 8 weeks to several months. As most of us know, many factors influence growth. Good nutrition and overall health affect growth, as do hormones in the body such as HGH.
- Mechanism: The pituitary gland is a structure in our brain that produces different types of specialised hormones, including growth hormone (also referred to as human growth hormone or HGH). The roles of growth hormone include influencing our height, and helping build our bones and muscles.
HCG
- Description: Human chorionic gonadotropin is a hormone produced primarily by syncytiotrophoblastic cells of the placenta during pregnancy. The hormone stimulates the corpus luteum to produce progesterone to maintain the pregnancy. Smaller amounts of hCG are also produced in the pituitary gland, the liver, and the colon.
- Functions: Normal levels of HCG in men and premenopausal women range from 0.02 to 0.8 IU/L. In early pregnancy, HCG levels can double every few days, peaking by about 10 weeks. After that, levels can either hold steady or begin to decline. Normal HCG levels during pregnancy can range from 20,000 to 200,000 IU/L.
- Benefits: In men, hCG acts like luteinizing hormone (LH). LH stimulates Leydig cells in the testicles, which results in the production of testosterone. LH also stimulates production of sperm within structures in the testicles called seminiferous tubules.
GHRP-2
- Description: Also known as Pralmorelin, GHRP-2 is a ghrelin agonist that has been used to counteract the effects of malnutrition. GHRP-2 is also administered to enhance endurance, improve bone density, boost the immune system and promote faster healing of wounds.
- Functions: Only GnRH pulses together with GHRP-2 + TRH infusion increased testosterone significantly from day 2 (peak increase of + 312%) through day 5 and serum E2 with > 80% from day 1 through day 3 (all P = 0.05).
- Mechanism: Chronic treatment with GHRP-2 failed to stimulate somatotroph cell proliferation and GH secretion and to promote longitudinal growth. GHRP-2-treated mice showed an increase in total body weight compared with placebo-treated animals, due to worsening of the body composition alterations typical of GHD animals.
- Downside: Compounded drugs containing GHRP-2 for injectable and nasal administration may pose risk for immunogenicity due to the potential for aggregation and peptide-related impurities. GHRP-2 also contains an unnatural amino acid, which adds to the complexity of peptide characterization.
- Instructions: As previously reported , a subcutaneous infusion of GHRP-2 for 270 minutes is safe. Accordingly, no adverse side effects were reported during a 30-day sc continuous infusion of GHRP-2 or 12 month oral administration of the drug in children.
PEG-MGF
- Description: PEG-MGF is a split variant of insulin-like growth factor-1 (IGF-1). It is present in the muscles, bones, tendons, brain, and heart tissues after an increased load of stress. Its main purpose is to promote faster recovery from muscle damage.
- Benefits: Primarily, MGF is used in conditions requiring anabolic enhancement, including bony and soft tissue repair (e.g., tendon, ligament, muscle) following injury, sarcopenia (muscle wasting), stroke, or heart attack.
- Instructions: Injecting PEG-MGF bilaterally, subcutaneously or intramuscular in the areas you want to target. It will circulate in your body binding to tissues that need to be replaced after a workout session.
Hexarelin
- Description: Hexarelin has cardioprotective activity in common cardiovascular conditions such as cardiac fibrosis, ischemic heart disease, cardiac dysfunction, and atherosclerosis.
- Functions: Serum IGF-I rose from a mean of 10.4 ± 3.9 (SD) nMol/1 to 14.5 ± 5.4 nMol/1 (p < 0.02) already after 7 days of Hexarelin administration (13), and remained essentially constant throughout the first 6 months of treatment (p < 0.0004) (Table 3). In 3 of the 5 children there was a further increase in the following months.
- Mechanism: Structurally, Hexarelin (Hexarelin Acetate) is similar in structure to GHRP-6 but without the appetite increase because of its inability to drastically increase Ghrelin levels which is responsible for the increased appetite and quicker gastric emptying.
- Instructions: Common dosing frequencies range from two to three times daily. It's important to space the doses evenly throughout the day to maintain stable blood levels. Some users prefer to take a higher Hexarelin dosage for bodybuilding before a workout to enhance the growth hormone liberation associated with exercise.
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FAQ
Q: Is BPC a steroid?
A: No, BPC 157 is not a steroid. It is a peptide pulled from human gastric juice.
Q: Why is BPC 157 banned?
A: The primary reasons cited by the FDA for the ban include: Lack of Clinical Trials: One of the FDA's major concerns is the absence of extensive, controlled clinical trials involving BPC 157. Most studies conducted so far have been on animals, and there is a scarcity of well-documented research on human subjects.
Q: Is BPC 157 a steroid or peptide?
A: Body Protection Compound 157 (BPC-157) is a peptide composed of 15 amino acids. Although the researchers who patented BPC-157 say that it was derived from a stomach protein, this claim isn't well-substantiated.
Q: Is BPC 157 natural?
A: From tissue repair to anti-inflammatory effects, this peptide seems to hold the key to accelerated recovery and enhanced well-being. BPC-157, or Body Protection Compound 157, is a synthetic peptide derived from a portion of the body's own protein known as Body Protection Compound.
Q: Is BPC 157 good for bones?
A: Abstract. Gastrectomy often results in increased likelihood of osteoporosis, metabolic aberration, and risk of fracture, and there is a need for a gastric peptide with osteogenic activity. A novel stomach pentadecapeptide, BPC-157, improves wound and fracture healing in rats in addition to having an angiogenic effect.
Q: Are peptides like steroids?
A: Peptides and steroids are distinct in their mechanisms of action, but they can both influence muscle growth and body composition, albeit in different ways. While peptides present a milder and safer alternative to anabolic steroids, it's essential to approach their use with the same level of care and responsibility.
Q: Is PT-141 nasal spray safe?
A: Is PT 141 safe? PT 141 studies are not extensive enough to draw definitive conclusions about its safety. Still, the studies that have been conducted point toward significant issues with flushing, nausea, and vomiting.
Q: Where is the best place to inject PT-141?
A: It is given as a shot under your skin, usually in the stomach or thighs.
Q: Can you drink alcohol on PT-141?
A: Before using PT-141, discussing any medications or supplements, you are taking with your doctor is essential. Certain medications, such as anticoagulants and birth control pills, may interact with PT-141 and increase the risk of side effects. Additionally, alcohol not be consumed while taking PT-141.
Q: Can I take sildenafil with PT-141?
A: Co-administration of PT-141 and sildenafil was safe and well-tolerated and did not result in new adverse events or adverse events that were increased in frequency or severity compared with monotherapy.
Q: Is follistatin 344 illegal?
A: Follistatin (FS), a myostatin-inhibiting protein, is prohibited according to chapter S4 of the "WADA Prohibited List 2022". While currently no approved pharmaceutical formulations of Follistatin are available, Follistatin can be bought on the black market.
Q: What is the difference between follistatin 315 and 344?
A: Follistatin 344 is the more general form of Follistatin, which “exclusively generates the serum circulating Follistatin 315 isoform of Follistatin.”Follistatin 315 is a more specific variation found primarily in blood circulation.
Q: Is follistatin a steroid?
A: Follistatin is present in the circulatory system and was proposed to be a transport protein analogous to steroid binding proteins in serum.
Is follistatin gene therapy safe?
Follistatin is a safe and potent inhibitor of this pathway with strong potential for broad applicability that can be extended to other muscle diseases.
Is follistatin gene therapy safe?
Follistatin is a safe and potent inhibitor of this pathway with strong potential for broad applicability that can be extended to other muscle diseases.
Q: Does Selank help with anxiety?
A: Studies revealed that Selank acts as an anxiolytic with stimulatory and cognitive enhancing properties.
Q: Is HGH a steroid?
A: No, HGH is a peptide hormone, not a steroid. A peptide is a substance from two or more amino acids. People often confuse human growth hormone (HGH) with other substances that can improve athletic ability, but HGH is not a steroid.
Q: Is it safe to take hGH hormone?
A: High levels of human growth hormone over a long period can produce irreversible acromegaly, but even smaller doses can lead to complications such as heart disease and diabetes. And because these hormones must be taken as injections, there are further administration risks such as a blood clot or dose error.
Q: Which is safer HGH or testosterone?
A: Testosterone: Both Are Safe, Sound Medical Treatments. There has been a history of abuse with HGH and testosterone, most visually in sports. But they are used extensively in medicine with usually only rare side effects when administered under a physician.
Q: Is HGH similar to steroids?
A: No, HGH is a peptide hormone, not a steroid. A peptide is a substance from two or more amino acids.
Q: How early is hCG pregnancy?
A: Trace levels of hCG can be detected as early as eight days after ovulation. That means you could get positive results several days before you expect your period to start. However, the first part of your cycle is more variable than the second, making it tricky to determine the best time for an early test.
Q: What happens if hCG is positive?
A: A high level of HCG indicates that a person is pregnant. A negative qualitative HCG test means a person is not pregnant. If they still suspect that they are pregnant, a person should repeat the test after a few days .
Q: What is the difference between MGF and PEG MGF?
A: PEG-MGF is Pegylated Mechano Growth Factor. It is a long-acting variant of MGF which is a split variant of IGF-1 (but its sequence differs from the systemic IGF-1 produced by the liver). IGF-I is spliced towards MGF which initiates hypertrophy and repair of local muscle damage.
Q: Is PEG MGF used before or after workout?
A: PEG-MGF is used not only for post-workout recovery, however. Thanks to its properties, the peptide will also prove useful for accelerating the healing of wounds or bone injuries, and will even help increase skeletal density.
Q: Is PEG-MGF systemic?
A: PEGylated MGF is systemic in nature, meaning that the method of administration is not important. Most people are using MGF in a fashion similar to IGF, meaning they inject the peptide intramuscularly in recently trained muscle groups, hoping for an increase in cell repair and proliferation of new cells.
Q: Is hexarelin better than Ipamorelin?
A: Both peptides offer potential contributions to anti-aging endeavors. Hexarelin's stimulation of growth hormone secretion can enhance skin elasticity and muscle tone, while Ipamorelin's selective release minimizes adverse effects, catering to varied physiological reactions and tolerance limits.
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