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Description
IGF-1 LR3 (Long R3 Insulin-Like Growth Factor-1) is a synthetic, extended-half-life version of IGF-1. Its modified structure improves stability and potency, making it a popular choice in research focused on muscle growth, recovery, and cellular regeneration.


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What is IGF-1 LR3?
IGF-1 LR3 (Insulin-like Growth Factor 1 Long R3) is a modified version of IGF-1, a peptide hormone that plays a key role in growth, development, and tissue repair. The "LR3" part of the name refers to a modification at the third amino acid of the peptide, which extends its half-life and enhances its biological activity.
●IGF-1 is a naturally occurring protein produced primarily in the liver, stimulated by growth hormone (GH). It is responsible for various growth and developmental processes in the body, such as cell regeneration, muscle growth, and bone health.
●LR3 Modification: In IGF-1 LR3, the substitution of the amino acid arginine at position 3 alters the peptide's structure, making it less likely to bind with IGF-binding proteins (IGFBPs). This modification means the peptide remains in its active form for a longer duration in the bloodstream, leading to an extended half-life and greater potency.
IGF-1 LR3 powder is typically the lyophilized (freeze-dried) form of the peptide, which requires reconstitution with sterile water or bacteriostatic water before use.
Clinical Data
Trade names
Long R3-IGF-1; IGF-1 Long R3 CAS
143045-27-6
Molar mass
9117.60
Formula
C400H625N111O115S9 Purity
Above 98%
Apprarance
White crystalline powder
Applications
IGF-1 LR3 is frequently studied for:
Muscle hypertrophy mechanisms
Cellular growth pathways
Recovery and tissue repair models
Performance and endurance adaptation
Anti-catabolic activity research
Key Features & Advantages
1. Enhanced Muscle Protein Synthesis
IGF-1 LR3 is valued in research for its ability to support lean muscle development, nutrient uptake, and anabolic activity.
2. Extended Half-Life
The LR3 modification significantly increases stability-lasting up to 20–30 hours, allowing longer activity compared to standard IGF-1.
3. Supports Recovery & Tissue Repair
Often used in studies involving muscle regeneration, collagen formation, and accelerated recovery after intense physical stress.
4. Increased Nutrient Delivery
Research shows IGF-1 LR3 can enhance glucose and amino acid transport, improving muscle fullness and performance adaptation.
5. Widely Used for Performance Research
Its stability, potency, and extended activity make IGF-1 LR3 a common peptide in performance-related investigations.
Stability & Storage Requirements
Store below –20°C for long-term stability
Short-term storage (1–2 weeks) possible at 2–8°C
Keep vial in a dry, dark environment
Avoid repeated freeze–thaw cycles to maintain integrity
Dosage
1 Standard Dosage
The dosage of IGF-1 LR3 can vary depending on individual goals, such as muscle growth, fat loss, or recovery. Standard dosages generally range between 20-100 mcg per day.
For Muscle Growth: 40-100 mcg daily.
For Fat Loss: 20-40 mcg daily.
For Recovery and Healing: 20-60 mcg daily.
It is important to note that individual responses to IGF-1 LR3 can vary, and it is recommended to start with a lower dose to assess tolerance before increasing.
2 Administration Method
IGF-1 LR3 is administered through subcutaneous injections. After reconstituting the powder with bacteriostatic water, it is typically injected into the fatty tissue of the abdomen or thigh.
Injection Frequency: Due to its long half-life, most users administer IGF-1 LR3 once daily, typically after a workout for muscle growth. Some users may opt for split doses to maintain more consistent levels of the peptide throughout the day.
3 Reconstitution
To reconstitute IGF-1 LR3 powder, it is necessary to add sterile or bacteriostatic water to the vial containing the peptide. Typically, the ratio is about 1-2 ml of water for each vial of IGF-1 LR3. After adding the water, gently swirl the vial to dissolve the peptide; do not shake vigorously, as this can degrade the peptide.
IGF-1 LR3 vs IGF-1 DES
1. Structure & Duration
✔ IGF-1 LR3
Modified version of IGF-1 with "Long Arg3" extension
Half-life: ~20–30 hours
Circulates longer in the bloodstream
Provides full-body, long-lasting anabolic effects
✔ IGF-1 DES
Shortened version of IGF-1 (amino acids 1–63)
Half-life: ~20–30 minutes
Very fast acting
Works locally at the injection site
2. Main Effects
IGF-1 LR3 - Systemic Effects
Supports overall muscle growth
Enhances protein synthesis and recovery
Increases endurance and performance
Promotes fat metabolism
Used during bulking, recomposition, or long cycles
IGF-1 DES - Localized Effects
Stimulates targeted muscle growth at injection site
Used pre-workout for weak-muscle groups
Supports fast repair after intense training
Common for spot-enhancement
3. Best Use Cases
IGF-1 LR3
Ideal for:
Full-body growth cycles
Lean mass and strength
Long-term anabolic support
IGF-1 DES
Ideal for:
Target-area muscle development
Post-injury recovery
Pre-workout localized boost
Correcting lagging muscle groups
4. Key Differences (Simple Table)
Feature IGF-1 LR3 IGF-1 DES Half-life 20–30 hours 20–30 minutes Effect area Whole body Injection site only Best for Overall gains Localized growth Injection timing Anytime Immediately before training Duration of action Long Very short Common cycle 4–8 weeks 2–4 weeks -
Our Advantages
1.Quality:every item is strictly tested by our professional staff and get ISO certificate.
2.Price: much lower than our peers since we are factory. A discount would be given when you make a large order.
3.Delivery: We have adequate stock so we can make the delivery within 24 hours after payment.
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Any needs, please contact me
Email: amyraws195@gmail.com
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