OTR-AC High Quality CAS:1025658-44-9

Description

OTR-AC, also called MK-2866 Ester, is MK-2866 (Ostarine) which has undergone esterification during chemical synthesis to maximise potency, biodistribution and half-life. The esterification of anabolic agents results in at least a 10-fold increase in half-life, which means that the active ingredient has the potential to remain bioactive ten times longer. This results in numerous benefits, such as decreased dosing frequency and more stable blood levels.

Clinical Data

OTR-AC Cycle

The OTR-AC cycle refers to a specific stack or combination of substances typically used in bodybuilding or athletic performance enhancement. This cycle involves the use of Ostarine (MK-2866), Testosterone (in various forms such as Cypionate, Enanthate, or Propionate), and Anavar (Oxandrolone). These compounds are popular for their ability to support muscle growth, fat loss, and overall physical performance while minimizing side effects compared to other more potent steroids.

Here's a breakdown of the compounds commonly included in an OTR-AC cycle:

1. Ostarine (MK-2866)

Type: Selective Androgen Receptor Modulator (SARM)

Purpose: Muscle preservation, fat loss, and strength increase.

Mechanism: Ostarine binds to androgen receptors in muscle and bone tissues, promoting muscle growth and fat burning without the harsh side effects of anabolic steroids.

Common Dosage: Typically taken in doses of 10-25 mg per day, depending on the user's goals and tolerance.

Cycle Length: 6-8 weeks.

2. Testosterone (Various Esters)

Type: Anabolic steroid (Testosterone is a natural male hormone)

Purpose: Muscle growth, strength increase, libido enhancement.

Types: Various testosterone esters are used in cycles, such as:

Testosterone Enanthate: A slow-release ester.

Testosterone Cypionate: Similar to Enanthate but with a slightly longer half-life.

Testosterone Propionate: A fast-acting ester.

Common Dosage: Generally 250-500 mg per week, depending on the ester used and the cycle length.

Cycle Length: 8-12 weeks for mass gain cycles, or 6-8 weeks for cutting phases.

3. Anavar (Oxandrolone)

Type: Oral anabolic steroid (mild steroid)

Purpose: Fat loss, muscle definition, and strength gain with minimal side effects.

Mechanism: Anavar increases red blood cell production and nitrogen retention in the muscles, improving overall muscle endurance and reducing body fat.

Common Dosage: Typically 20-80 mg per day, depending on the user's goals and experience.

Cycle Length: 6-8 weeks.

Typical Cycle Structure (OTR-AC Cycle):

Ostarine (MK-2866): 10-25 mg per day for 6-8 weeks.

Testosterone (Cypionate/Enanthate/Propionate): 250-500 mg per week for 8-12 weeks.

Anavar (Oxandrolone): 20-80 mg per day for 6-8 weeks, typically used for the last 4-6 weeks of the cycle for cutting or muscle definition.

Benefits of OTR-AC Cycle:

Increased Lean Muscle Mass: Testosterone is the primary muscle-building compound, and Ostarine helps preserve lean muscle.

Fat Loss: Ostarine can assist in fat loss while Anavar enhances this effect.

Improved Strength and Endurance: Anavar and testosterone both boost strength, and Ostarine enhances endurance.

Reduced Side Effects: Compared to traditional steroids, Ostarine and Anavar have a lower risk of estrogenic side effects like gynecomastia or water retention.

Improved Recovery: Testosterone enhances recovery, helping users train more frequently with less fatigue.

Side Effects and Considerations:

Testosterone: Common side effects include acne, hair loss, aggression, and potential suppression of natural testosterone production (requiring post-cycle therapy).

Ostarine: Generally mild, but potential suppression of natural testosterone with long-term use.

Anavar: Mild side effects, but it can be liver-toxic in higher doses or prolonged use.

Post-Cycle Therapy (PCT):

Since the use of testosterone can suppress natural testosterone production, a PCT is recommended after the cycle to restore normal hormone levels. PCT commonly includes medications like Clomid or Nolvadex to stimulate natural testosterone production.

Potential Benefits of OTR AC

OTR-AC and Diabetes

Preliminary research suggests that Ostarine (OTR-AC) may have therapeutic potential in diabetes or individuals at risk for diabetes. Studies have shown that treatment with Ostarine leads to decreased fasting blood glucose levels, reduced insulin levels, and improved insulin resistance. These findings indicate that selective androgen receptor modulators (SARMs) like OTR-AC may hold promise as potential therapeutic options for diabetes. 

OTR-AC and Lean Body Mass

Studies conducted on elderly men and postmenopausal women have shown that OTR-AC (GTx-024) has the potential to increase total lean body mass and improve physical function in a dose-dependent manner. These findings suggest that OTR-AC could be utilized for the prevention and treatment of muscle wasting caused by cancer and other chronic diseases. 

OTR-AC and Cholesterol

In the same study, it was observed that Ostarine (OTR-AC) caused a dose-dependent decrease in LDL and HDL cholesterol levels. However, it's important to note that the average LDL/HDL ratio remained within the low cardiovascular risk category across all doses. 

OTR-AC and Postmenopausal Osteoporosis

In animal studies involving ovariectomized rats, Ostarine (OTR-AC) has shown promising effects on early bone healing and potential as a therapy for osteoporosis. It has demonstrated positive impacts on bone microstructure parameters. Although the biomechanical qualities of the bone have not shown significant changes in short-term therapy, longer treatment courses might yield improved results. 

OTR-AC and Cancer Cachexia

Cancer cachexia, a condition characterized by muscle wasting in cancer patients, has been shown to have detrimental effects on physical function and overall health outcomes. While the positive effects of OTR-AC, a selective androgen receptor modulator, on lean body mass and physical function in cancer patients with cachexia, have been demonstrated in a study, it's important to note the limitations of small sample sizes and diverse cancer types studied. 

OTR-AC and Improvement of Muscle Tissue

Ostarine, as a selective androgen receptor modulator, has garnered attention for its potential benefits in enhancing physical performance and promoting muscle growth. Animal studies, particularly those conducted on rats, have revealed interesting findings. One study observed increased muscle vascularization through higher capillary density and enhanced muscle enzyme activity, without causing hypertrophy in muscle fibers. 

Another investigation demonstrated increased muscle mass in rats, associated with elevated expression of myogenin, MyoD, and MyH after Ostarine administration. These findings suggest that OTR-AC activates the androgen receptor to support muscle tissue proliferation and differentiation. 

How OTR-AC Works

Ostarine, a member of the selective androgen receptor modulator (SARM) family, exerts its mechanism of action by binding to androgen receptors in the body. This interaction initiates a series of conformational changes within the androgen receptor, leading to altered interactions with the coactivator and corepressor proteins found in various tissues. Consequently, Ostarine modifies the receptor's ability to regulate gene expression, resulting in tissue-specific effects.

This selective modulation of androgen receptors allows Ostarine to promote muscle growth and potentially improve physical function. Unlike testosterone or non-selective synthetic anabolic steroids, Ostarine's tissue-specificity minimizes undesirable side effects on the prostate, skin, and hair, making it a promising alternative for anabolic purposes. By targeting androgen receptors, Ostarine offers the potential to increase muscle mass and enhance physical performance while reducing the risk of unwanted adverse effects commonly associated with other compounds.

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