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Description
RU58841 (CAS 154992-24-2) represents a distinctive class of non-steroidal antiandrogens within the arylhydantoin family, initially developed by Roussel Uclaf during the 1990s as a topical therapeutic candidate for androgen-dependent dermatological conditions. Though the compound progressed to Phase 2 clinical trials for acne and androgenetic alopecia before being discontinued, it has persisted as a valuable research tool for investigators exploring topical androgen receptor antagonism without systemic hormonal disruption.


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Clinical data
Trade names RU58841;PSK-3841;HMR-3841 CAS 154992-24-2 Molar mass 369.344 MF C17H18F3N3O3 Purity Above 98% Apprarance White Crystalline Powder Core Characteristics
Chemical Class: Nonsteroidal antiandrogen (NSAA) also known as PSK-3841 or HMR-3841.
Intended Mechanism: Binds to scalp hair follicle receptors to block DHT action without lowering systemic hormone levels.
Stability: Highly sensitive to moisture and degrades rapidly in the presence of water.
Advantages
RU58841 is an experimental topical anti-androgen studied mainly for androgenetic hair loss. Its potential advantages are:
Blocks androgen receptors directly in the scalp, targeting both testosterone and DHT activity.
Topical use may reduce systemic hormonal effects compared with oral anti-androgens.
Does not inhibit 5-alpha-reductase, so it should not directly lower systemic DHT like finasteride.
Early studies suggested it could help preserve hair follicles and support hair growth.
Is RU58841 the same as finasteride?
NO, They target androgen-related hair loss differently:
Finasteride blocks the enzyme 5-alpha-reductase, reducing conversion of testosterone into DHT. It is an approved, well-studied medication, usually taken orally, though topical formulations also exist.
RU58841 directly blocks androgen receptors in the scalp.
Both aim to reduce androgen effects on hair follicles, but they are not interchangeable. Finasteride has much stronger clinical evidence and regulated dosing;
Key Features
High Purity (≥98%)
Strict quality control ensures consistent and reliable compositionExcellent Batch Consistency
Uniform quality across different production lotsStable Chemical Structure
Suitable for long-term storage under proper conditionsFine Crystalline Form
Easy handling and accurate measurement in lab environmentsTrusted Reference Compound
Widely recognized in pharmaceutical and academic researchPackaging Options
10g / 50g / 100g
500g / 1kg
Custom packaging available
Shipping & Handling
Discreet and secure packaging
Stable international shipping
Tracking provided after dispatch
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Stable high-purity raw materials
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