High Purity Peptides IGF1-LR3 0.1mg/vial

Description

IGF 1-LR3 is a synthetic polypeptide hormone which is a modified analogue of IGF-1 (human insulin-like growth factor 1) and as such its properties are similar to those of insulin. IGF 1-LR3 stands for Long arginine-3 Insulin-like Growth Factor. It is also known as LR3-IGF-1, Long R3 IGF-1 or as Long arginine 3-IGF-1. IGF 1-LR3 is made up of 83 amino acids and at position 3 of its amino acid sequence; it has a substitution of Arginine in the place of Glutamic acid. Its N-terminus has 13 more amino acids which make it "long" as it has 83 amino acids compared to the original 70 amino acids found in IGF-1. The alteration in its amino acid sequence averts protein binding (this deactivates the hormone), enhances half-life (stability), and ensure that it retains the pharmacological activity of IGF-1 as an agonist to the IGF-1 receptor. This long version (IGF 1-LR3) of IGF has a higher efficacy compared to the original IGF-1. Its higher potency of about 3 times that of IGF-1 is as a result of increased binding sites and its half-life is also longer at about 20-30 hours compared to 20 minutes for IGF-1.In addition to the transportation of glucose and amino acids into the cells to assist in protein synthesis, this biomolecule brings about fat metabolizing properties. Scientific research results indicate that IGF 1-LR3 increases neuro-functions and the retention of nitrogen in the cells, and promotes muscle cell hyperplasia. IGF 1-LR3 has a molecular mass of 9.200 Daltons and its chemical formula is C₉₉₀H₁₅₂₈N₂₆₂O₃₀₀S₇. Its amino acid sequence is MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPAKSA.

How does IGF1-LR3 work?

IGF-1 LR3 (Insulin-like Growth Factor 1 Long R3) is a synthetic, modified version of IGF-1, a naturally occurring hormone similar in structure to insulin. IGF-1 LR3 is engineered to have an extended half-life and enhanced potency compared to natural IGF-1, making it a popular research peptide for muscle growth, recovery, and metabolic studies.

Mechanism of Action:

Binding to IGF-1 Receptors:

IGF-1 LR3 binds to IGF-1 receptors on cells, triggering intracellular signaling cascades.

This activates pathways like the PI3K-AKT and MAPK pathways, which are crucial for cell growth, survival, and proliferation.

Increased Protein Synthesis:

Stimulates muscle cells to synthesize proteins, leading to growth and repair.

This makes it particularly interesting for applications in muscle wasting or injury recovery research.

Enhanced Glucose Uptake:

Promotes glucose uptake into cells, reducing blood glucose levels and improving cellular energy availability.

Inhibition of Apoptosis:

Prevents programmed cell death in muscle and other tissues, contributing to tissue maintenance.

Prolonged Activity:

The modification to create LR3 involves replacing the arginine at position 3 and removing the IGF-binding protein-binding region.

These changes extend its half-life (up to 20-30 hours) and reduce its affinity for IGF-binding proteins, increasing bioavailability.

Common Applications in Research:

Muscle Growth and Recovery: IGF-1 LR3 is studied for its anabolic effects on muscle tissue.

Tissue Repair: It aids in the repair of various tissues, including cartilage, tendons, and ligaments.

Anti-Aging Studies: Research explores its role in promoting cell regeneration and reducing signs of aging.

Glucose Metabolism: Studies investigate its potential for regulating blood sugar levels in diabetes research.

Why is IGF1-LR3 so popular?

1. Extended Half-Life

Natural IGF-1 has a short half-life (~20 minutes), limiting its practical utility.

IGF-1 LR3 has a significantly extended half-life (20-30 hours), allowing for sustained activity in the body and reduced dosing frequency.

2. Greater Potency

IGF-1 LR3 is more potent than natural IGF-1 due to its structural modifications, which:

Prevent it from binding to IGF-binding proteins (IGFBPs) that would normally reduce its activity.

Enhance its ability to bind to IGF-1 receptors on muscle, fat, and other tissues.

3. Muscle Growth and Recovery

Its anabolic effects on skeletal muscle are highly valued, making it popular for studies related to:

Muscle repair after injury.

Prevention of muscle wasting (e.g., in cachexia or aging).

Enhancing muscle hypertrophy (growth) through increased protein synthesis.

4. Versatility in Research

IGF-1 LR3 is studied across various disciplines, including:

Tissue repair: Examining its effects on cartilage, tendon, and ligament healing.

Metabolic health: Investigating its potential for improving glucose metabolism and insulin sensitivity.

Anti-aging: Research into cellular regeneration and longevity.

5. Targeted Action

It promotes localized effects in tissues with IGF-1 receptors, reducing off-target activities.

This specificity makes it ideal for focused studies, such as targeted muscle or organ growth.

6. Reduced Glucose Competition

IGF-1 LR3 enhances glucose uptake without competing with insulin as much as natural IGF-1, reducing the risk of severe hypoglycemia during use.

7. Widespread Interest in Sports and Fitness

Though its use outside research is often regulated or banned, IGF-1 LR3 is popular in discussions about athletic performance due to its potential to:

Increase lean body mass.

Accelerate recovery times.

Improve strength and endurance.

8. Convenience

The long-lasting nature of IGF-1 LR3 reduces the need for frequent administration, making it more practical in experimental protocols compared to natural IGF-1.

Why Is Igf-1 Prescribed?

FDA-approved HGH can be legally prescribed for a limited number of conditions including:

• Hormone deficiency that causes short stature in children;

• Long-term treatment of growth failure due to lack of exogenous GH secretion;

• Adult growth deficiency

• Long-term treatment of short stature associated with Turner Syndrome;

• Adult short bowel syndrome;

• Adult deficiency due to rare pituitary tumors or their treatment; and

• Muscle-wasting disease associated with HIV/AIDS.

Why Should You Use Igf-1?

The most important feature of IGF-1 is its ability to cause hyperplasia in the human body. The body of a person who is on steroids goes through hypertrophy, this means that they will only be increasing the size of the existing cells in their muscles. On the other hand, IGF-1 leads to hyperplasia which purports the growth and development of new cells in the muscles. Generally, you will accomplish much more in terms of muscle density and size at a normal genetic level.

In other words, the weight gain that you will experience from the use of IGF-1 is not due to retention of water. The weight gain is caused by actual muscle growth and is a long term effect. As compared to steroids which can cause water retention and adverse side effects the weight gain from Insulin-like Growth Factors is from solid muscle gain.

What May Be The Benefits Of Igf-1/Lr3?

Muscle hypertrophy effects

Conserves muscle in heifers

Increase lean muscle mass

Improve athletic performance

Improve muscle recovery after workouts

Reduce recovery time after injuries

Boost muscle protein synthesis

Reduce Body Fat

Facilitates protein synthesis in the body.

Regulates the storage of fat and channels it to be used for the production of energy.

Increases metabolism

Increases the regenerative properties of the body's nerve tissues.

Upregulates anti-oxidant benefit and ligament strength

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