Sarms Powder SR9011

Description

SR9011, often misclassified as a Selective Androgen Receptor Modulator (SARM), is a synthetic compound developed to target Rev-ErbA proteins, key regulators of circadian rhythms and metabolic processes. Initially researched for metabolic disorders and sleep regulation, its application in bodybuilding emerged due to its ability to enhance endurance and fat loss. Unlike traditional SARMs, SR9011 does not interact with androgen receptors, offering a unique mechanism that appeals to athletes seeking non-hormonal performance enhancers.

What is SR 9011?

SR 9011 is a synthetic compound known as a Selective Androgen Receptor Modulator (SARM), which specifically targets the Rev-ErbA receptor. Developed by the Scripps Research Institute, SR 9011 is often researched for its potential applications in enhancing physical performance and metabolic activity. By binding to the Rev-ErbA receptor, SR 9011 can influence various physiological processes, including circadian rhythm, lipid and glucose metabolism, and the regulation of mitochondrial function. This makes it a subject of interest for scientists looking to address conditions such as obesity, diabetes, and cardiovascular diseases.

One of the notable effects of SR 9011 is its ability to increase exercise capacity. Studies in animal models have demonstrated that administration of SR 9011 can significantly enhance endurance and physical performance. This is largely due to the compound's impact on skeletal muscle mitochondria, leading to an increase in energy expenditure and a reduction in stored fat. These properties suggest potential uses for SR 9011 not only in sports and fitness but also in medical scenarios where improving metabolic health and physical capacity is beneficial.

SR 9011 Molecular Mechanism: The Circadian Metabolic Switch

Chemical Profile

●IUPAC Name: (2R)-2-[(2−chlorophenyl)methylsulfanyl]−N−[2−(2−methoxyphenyl)ethyl]propanamide[(2−chlorophenyl)methylsulfanyl]−N−[2−(2−methoxyphenyl)ethyl]propanamide

●Molecular Formula: C₁₉H₂₂ClNO₂S

●Molecular Weight: 379.9 g/mol

●Solubility: Lipophilic (soluble in DMSO, ethanol; negligible water solubility).

Mechanistic Innovations

●REV-ERB Activation: Binds REV-ERB receptors, repressing BMAL1/CLOCK genes to reset peripheral circadian clocks in muscle and liver.

●Mitochondrial Biogenesis: Upregulates PGC-1α and NRF-1, increasing mitochondrial density by 50% in skeletal muscle (2021 murine study).

●Lipid Oxidation: Enhances CPT-1 and PDK4 expression, shifting energy utilization from glucose to fatty acids.

Unique Pharmacodynamics

●Non-Hormonal Pathway: Avoids androgenic, estrogenic, or glucocorticoid side effects.

●Circadian Synchronization: Optimizes nutrient partitioning by aligning metabolism with natural light/dark cycles.

●Anti-Inflammatory Effects: Reduces TNF-α and IL-6 via REV-ERB-mediated NF-κB suppression.

SR 9011 stack

Use SARM SR9011 for Bodybuilding alone helps the bodybuilder increase energy output, muscle recovery, and stay awake.

However, SR 9011, when used in combination with anabolic SARM, increases energy availability, accelerates recovery time, accelerates muscle repair and growth, while burning more fat and staying awake.

Because of these features, the SR 9011 for bodybuilding can be used for stacking, expansion, cutting, or maintenance, and even for post-cycling or continuing cycling.

Why is SR 9011 available for post-cycle cycling? This is because SR 9011 counteracts the drop in energy caused by falling testosterone levels in the body. This way, during PCT, while testosterone levels are still recovering, you can still get an energy boost, allowing you to keep exercising and burning fat, and avoid the loss of muscle mass that occurs during PCT.

●SR 9011 for bodybuilding stacking for expansion purposes is as follows (maximum period of 12 weeks) :
●SR 9011 10 mg / day
●RAD 140 10 mg / day
●MK 677 10 mg / day
●LGD 4033 5 mg / day
●SR 9011 for bodybuilding is stack for cutting purposes as follows:
●SR 9011 20 mg / day
●RAD 140 15 mg / day
●MK 2866 25 mg / day

SR9011 Dosage & Cycle Length

You could use this indefinitely. It's not anabolic, and in no studies on mice were any side effects noted. However, it's never been through human trials. This applies to both SR-9011 and its close variant SR-9009. So I would be wary of using it that way.

Therefore, I always keep a cycle length of 12 weeks or less. Then I give my body at least a two-month break. That allows it to reset and for me to see if there are any problems.

In terms of SR9011 dosage, you're in the same ballpark as with Sr9009.

10 mg is a low dose, 20 mg typical dose, and 30 mg is a high dose. Although effects are dose-dependent, doses above 50 mg in humans (anecdotal bodybuilding community evidence I've been researching, along with my own experiences) suggest that it starts to plateau between 30 mg and 50 mg.

So for me, my recommendation if you are using it on its own or in a stack is 10 mg to see how it goes. Kick it up to 15 mg or 20 mg after that, don't go above 30 mg.

I'd also dose it in the morning as a single dose. Although some people split up, you are running the danger of more strongly altering your circadian rhythm through the night. This can lead to problems down the line with altered sleep patterns.

Post Cycle Therapy (PCT) Considerations

Since SR9011 doesn't suppress the HPTA axis, PCT isn't typically required. However, some users incorporate mild PCT (e.g., 10 mg Tamoxifen for 2 weeks) to address potential cortisol fluctuations or psychological dependency on enhanced performance.

Safety and Side Effects

Reported side effects include insomnia (if dosed late), headaches, and mild gastrointestinal distress. Long-term risks remain unknown due to limited human studies. Animal studies show no significant toxicity at therapeutic doses, but chronic use impacts circadian genes, warranting cautious use.

Legal and Regulatory Status

SR9011 is not approved for human consumption and is classified as a research chemical. Its legality varies-banned in competitive sports under WADA but unregulated in many countries. Users should verify local laws and source purity, as the grey market poses contamination risks.

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