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What is Oxandrolone (Anavar)?
Oxandrolone a unique oral anabolic steroid hormone that is also known as Anavar. Anavar was first synthesized in 1962 and has been used in the medical treatment of catabolic disorders for over 30 years. Anavar is unique because it has great oral bioavailability (can be taken my mouth) and is resistant to liver metabolism. Anavar also does not get aromatized into estrogen compared to testosterone. The primary use of Anavar is to prevent frailty and the loss of muscle mass due to aging (sarcopenia) and other related catabolic clinical disorders such as HIV -related muscle waiting, severe burn injuries, trauma after surgery and hepatitis.
Anavar has been shown to:
1) Decrease visceral fat and total body fat
2) Increase protein synthesis in skeletal muscle
3) Increase dietary energy and protein intake
4) Increase nitrogen retention
5) Increase muscle function, growth, strength and physical activity level
6) Substitute for the natural loss of androgen and estrogen hormones
How does Oxandrolone (Anavar) work?
Anavar increases muscle mass in three ways
1) Inducing protein synthesis in the body
2) Up regulating the androgen receptor in skeletal muscle.
3) Increasing IGF-1 (insulin-like growth factor)
Anavar given to healthy men, has been shown to increase protein synthesis by as much as 44% and improve effects of resistance training.
What are the indications and usage for Anavar (Oxandrolone)?
Anabolic Androgenic Steroids are indicated in patients chronic wasting conditions (the loss of muscle mass) to prevent frailty. Such conditions include sarcopenia, AIDS related muscle wasting, severe burn injury, trauma following surgery and other catabolic disorders. Anavar is approved by the FDA for the treatment of patients with prolonged use of corticosteroids to prevent protein catabolism and has been used to promote weight gain after extensive surgery, during chronic infectious states, or after severe trauma.
How is Oxandrolone (Anavar) absorbed?
Anavar is an oral medication that is absorbed across the gastrointestinal tract. Peak serum concentrations of Anavar occur within 1 hour after ingestion. In the body, Anavar is 95% bound to protein, which may contribute to the steroid's stability and resistance to breakdown by the liver.
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