GW501516/Cardarine High Quality CAS:317318-70-0

Description

Often Cardarine is counted among the non-steroidal selective androgen receptor modulators (SARMs) because the mode of action is similar. But if one takes a closer look, GW501516 is not a SARM but an activator (agonist) of the PPARδ receptor. While SARMs act specifically at the androgen receptor, the agonist Cardarine works selectively at the PPARδ receptor. PPARs stand for peroxisome proliferator-activated receptors. Among other things, they control proteins involved in energy consumption. PPARδ can be found in almost every tissue in the human body. Primarily, the receptor controls the expression – i.e. the translation of genetic information into proteins – of genes that act on lipid metabolism. It also has an important function in cell growth – including the growth of fat cells. A tremendous reduction in body weight has been observed in obese animals.

Originally, Cardarine comes from medicine. Here it was developed in the 1990s to counteract or cure metabolic diseases, obesity, diabetes as well as cardiovascular diseases.

Clinical Data

How Does Cardarine Work

Researchers have found that Cardarine promotes the burning of fat instead of glucose for energy. This essentially increases time to exhaustion, by reserving glucose stores prolonging exercise endurance capacity. Thus, the body utilizes fatty acids, as opposed to relying on glucose for energy improving exercise capacity.

Carardine or GW501516 was originally created by Ligland Pharmaceuticals and GlaxoSmithKline with the goal of potentially treating metabolic disease such as diabetes and hyperlipidemia.

Due to its selective action, cardarine is often thought of as a SARM. However, cardarine is what's known as a peroxisome proliferator-activated receptor (PPAR) agonist. Activation of the PPAR-delta pathway causes a sudden increase in endurance and accelerated metabolism while lowering blood lipid levels.

It entered clinical development as a drug candidate for metabolic and cardiovascular disease states, due it's promising benefits on blood lipid levels.

Despite these promising early results, further investigation and development of GW501516 was discontinued in 2007 after observations in animal studies of its association with the rapid induction of cancers in several organs (liver, stomach, tongue, skin, bladder, ovaries, womb and testes [R].

GlaxoSmithKline was about to embark on Phase III clinical trials. Phase III is the last step required before FDA approval, which involves large, double-blind-placebo controlled trials. GSK found that GW501516 had long term toxicity.

Mice that had been given GW501516 over their lifespan (2 years), developed cancer at a higher rate, than their drug free cage mates.

To establish that cardarine was safe for use, at an even lower dose, would require conclusive evidence, that these same effects did not occur, with a 70-year trial.

Without the established proof, the F.D.A. would likely pose that the potential risks of using the drug to be greater than the actual dangers of high cholesterol.

Cardarine Benefits

Exercise Performance

Studies have shown that cardarine can improve exercise performance. A study published in the journal Cell conducted by Ronald M. Evans, an American biologist and Professor and Head of the Salk's Gene Expression Laboratory, investigated the effects of GW501516 on mice and found extraordinary results. After just four weeks of GW501516 application, the mice increased their endurance-how far they could run, and for how long-by as much as 75%.

After eight weeks of GW501516, the mice could run for nearly an hour and half longer than their drug-free peers.

Researchers believe the exact mechanisms work by mimicking the effect of endurance exercise on one particular gene: PPAR-delta.

Weight Loss

With a shift in energy metabolism, weight loss will follow. Like all genes, PPAR-Delta issues instructions to other cells, on how to work and how to utilize fuel for energy. GW501516 essentially reconfigures the chemical message signaling to break down body fat through lipolysis while simultaneously suppressing the message to break down sugar for energy. In exercise terms, GW501516, helps delay muscle fatigue, which in turn will help you burn more calories and induce greater weight loss with prolonged exercise duration.

Improves Endurance

By burning body fat and prolonging exercise capacity, endurance capacity will improve. Burning fat for energy, and saving carbohydrates or glycogen means it takes longer to hit, "the wall". Improved exercise volume combined while inhibiting the use of glycogen, will improve exercise endurance capacity.

Metabolic Syndrome

Metabolic syndrome, is a cluster of symptoms. It includes things like obesity, high blood pressure, and high blood sugar – precursors to heart disease and diabetes. The first trials of cardarine, showed promising results, lowering bad cholesterol and increasing good cholesterol, while also lowering insulin levels and triglycerides.

Is Cardarine Legal

Cardarine is classified as an investigational new drug by the FDA, meaning that it is still being studied and has not been approved for human use. As such, it is illegal to sell or distribute Cardarine in the U.S. for any purpose other than FDA-approved clinical trials.

Due it's role as a metabolic modulator and performance enhancer, Cardarine was added to the list of banned substances controlled by the World Anti-Doping Agency (WADA) in 2009.

You can legally buy and use Cardarine in every country in the world except for Australia. In Australia, it's considered as a Schedule 9 compound by the TGA which means that it's illegal even with a doctor's prescription. Cardarine however is distributed by black or grey market research laboratories, making potency, as well as quality highly questionable.

Intake and dosage of Cardarine

Please always follow the manufacturer's instructions exactly when taking and dosing GW501516, which you will find on the product. In general, the following applies to Cardarine:

10 to 20 milligrams per day for six to a maximum of twelve weeks at a time

For mass building, 10 milligrams daily for up to twelve weeks is sufficient

In the diet phase, 10 to 20 milligrams is suitable for twelve weeks

Most users limited their Cardarine regimen to eight weeks. Hardcore users also used GW501516 fat loss supplements for up to twelve weeks. However, you should not use Endurobol for longer at a stretch and then do a PCT.

For higher dosages of around 20 milligrams daily, you should spread the intake over two doses a day. If you only take 10 milligrams, you can take the supplement when you want. Many users do this before workouts to get the full effect in terms of energy boost, endurance increase, strength increase, etc.

Cardarine experience: What do users say?

Since there are no useful scientific studies, we asked users of Endurobol about their personal experiences. Overall, all users actually made the experience that Cardarine is very potent – that is, extremely strong. Both strength athletes and track and field athletes stated that it was one of the most massive endurance and energy boosters they had ever used.

Almost all users stated that they noticed enormous losses in body fat. There was also an improvement in muscle gain. In addition, almost all athletes said that their overall performance and energy levels were dramatically increased. Athletes in particular reported increased endurance. But bodybuilders could also rejoice. They had more strength and could better define the body.

Users who used Cardarine for fat loss in dieting reported feeling more energy and performance than usual. Side effects such as lethargy, lack of strength, etc., which are otherwise common during diets, were completely gone or significantly reduced. The experience of Cardarine users was at least 1 kilogram of body fat on a regimen that lasted 4 to 6 weeks.

None of the users spoke of serious side effects. A few stated that they had mild sleep problems at the beginning of the cycle, but these subsided after a short time.

Our Advantages

1.Quality:every item is strictly tested by our professional staff and get ISO certificate.
2.Price: much lower than our peers since we are factory. A discount would be given when you make a large order.
3.Delivery: We have adequate stock so we can make the delivery within 24 hours after payment.
4.Perfect Reshipping policy has been made to protect customers max bennefits and reduce the potentical losses.
5.Good after-sale service: always keeping track on the status of your parcel until delivered and trying our utmost to solve customers problems entounered
6.main products:Raw steroids,human growth hormone,Semi-finished oils,bodybuilding peptides,SARMs raws,Anabolic steroids