Finasteride CAS:98319-26-7

Description

Finasteride, also marketed under the brand names Propecia and Proscar, was first developed as a pill to treat Benign Prostatic Hyperplasia (BPH), also known as an enlarged prostate. Like Minoxidil, when Finasteride was being tested, researchers found that hair growth was a side effect in men experiencing hair loss. The oral medication was FDA approved to use for androgenetic alopecia in 1997 at a dose of 1 mg.

Clinical Data

How does finasteride work?

FDA-approved and approved in the UK, finasteride prevents the androgen-dependent miniaturisation of hair follicles. It does this by blocking the type II 5 alpha reductase enzyme, thereby preventing the conversion of testosterone to dihydrotestosterone (DHT).

DHT is an androgen produced from testosterone. It is the hormone responsible for male pattern hair loss. In men susceptible to male pattern hair loss, DHT can bind to receptors in the hair follicles, causing them to shrink and eventually die. Taking oral finasteride in 1mg doses can lower serum and scalp DHT levels by 60%.

Is finasteride effective for hair loss?

The first questions many of our patients have are, "Does finasteride stop hair loss?" or "How effective is finasteride for hair loss?"

For most patients, the answer is yes - when using finasteride for hair loss, a comparison will show distinct results. However, finasteride's long-term results can vary between patients.

Finasteride medication is proven to prevent further hair loss in over 95% of men who take it. Clinical studies have shown that for 83% of participants with crown balding, the finasteride results after 2 years of treatment included a complete halt in hair loss.

In addition to this, a 10-year follow-up study examining finasteride's long-term efficacy suggests significant lasting increases in hair growth after long-term finasteride use.

A finasteride hair treatment is most effective on the vertex scalp, less on the frontal scalp, and least effective on the temporal regions. This means that if you are using finasteride for your crown, the results are more likely to be positive than if you use finasteride for a hairline that's receding.

Alongside improved hair counts, finasteride can lead to increased hair thickness. This extra thickness can give the impression of a fuller head of hair, resulting in a more satisfactory finasteride before and after comparison.

Will finasteride regrow hair?

Baldness results from your hair follicles slowly shrinking over time, creating finer, wispier hair. Eventually, hair follicles will not grow new hair. That being said, as long as the follicle remains intact, patients can grow new, thicker hair when using finasteride for hair growth.

Hair regrowth from finasteride may be possible in some patients. As finasteride is most effective on the vertex scalp, finasteride crown regrowth is more commonly seen than that of the temporal regions or frontal scalp.

A total of 66% of patients will achieve moderate finasteride hair regrowth, and 5% will achieve marked finasteride regrowth.

How long does it take for finasteride to work?

Many male patients exploring solutions for their hair loss ask Dr Bonaros questions like "How long does finasteride take to work?" and "When does finasteride start working?"

Patients should continue finasteride hair loss treatments for at least 1 year so the finasteride results can be assessed effectively. Long-term studies have found that the patient's finasteride results after 1 year may predict its effectiveness going forward. Patients who fail to respond within the first 12 months are likely to be non-responders in the long term, too.

It is important to note that finasteride needs to be continued indefinitely to maintain efficiency. The medication has a short half-life and only works while it is used.

What's the Difference Between Minoxidil and Finasteride?

Minoxidil and Finasteride have two very different roles in treating androgenetic alopecia in men and women. Finasteride blocks the DHT to prevent hair loss from occurring in the first place. Because it also prevents miniaturization of the hair follicles, existing hair does not thin and new hair is able to grow. Minoxidil works at your scalp's surface, enlarging the hair follicles.

Can You Use Minoxidil and Finasteride at the Same Time?

Because Minoxidil and Finasteride complement each other well as a treatment for androgenetic alopecia. Dermatologists often prescribe the two medications together. As a matter of fact, research has proven that not only can the medications be used together, but doing so has higher efficacy than using just one of the medications alone. (03)

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