CJC1295 With DAC Powder

Description

CJC-1295 is a synthetic GHRH (growth hormone releasing hormone) analogue made up of 30 amino acids. It has been found to be highly effective with regards to the increase of growth hormone secretion and IGF-1 without negatively affecting the pulsatility of GH secretion.

CJC-1295 is often combined with Ipamorelin due to its enhanced specificity as a GHRH. This peptide generates similar increases in growth hormone secretion, but without the appetite stimulation and increase in cortisol, acetylcholine, prolactin, and aldosterone seen with other peptides in its class. This peptide has been found to be very well-tolerated and perfect when combined with Ipamorelin.

What does CJC-1295 with DAC do?

CJC-1295 with DAC is a synthetic peptide that is sometimes used in the realm of sports performance and anti-aging medicine. It's a modified version of the growth hormone-releasing hormone (GHRH) known as CJC-1295. The addition of DAC (Drug Affinity Complex) prolongs its half-life.

CJC-1295 with DAC works by stimulating the pituitary gland to increase the production and release of growth hormone (GH). Growth hormone plays a crucial role in various physiological processes, including growth, metabolism, and tissue repair. By increasing GH levels, CJC-1295 with DAC may promote muscle growth, fat loss, improved recovery from exercise, and potentially offer anti-aging benefits such as improved skin quality and cognitive function.

However, it's important to note that the use of peptides like CJC-1295 with DAC outside of legitimate medical purposes and without proper medical supervision is controversial and potentially risky.

CJC 1295: GHRH & DAC

GHRH (growth hormone releasing hormone) is produced in the hypothalamus. Its pulsatile release from the hypothalamus triggers a pulsatile release of GH from the pituitary gland. GHRH has a very short half-life of only a few minutes (half-life = the time required to remove half of the substance from the blood. The shorter the half-life, the more rapidly the substance is removed from the body, and the less its effect on the body).

The first 29 amino acids of GHRH is the active segment. They are available as a manufactured peptide called Sermorelin. Sermorelin was further modified to increase its half-life to 30 minutes. This is called CJC 1295. CJC-1295 was further modified by adding DAC (Drug Affinity Complex) to it. DAC binds to a blood protein called albumin, which increases its half-life to 8 days. It is called CJC 1295 + DAC. CJC 1295 can also be compounded in a non-DAC form which mimics a more normal physiologic GH spike each night.

The longer half-life from the DAC binding to albumin means injections are only required once or twice per week. However, the long half-life and relatively constant blood level provide a constant stimulus for GH release from the pituitary through the GHRH receptor, which is not physiological. This can decrease the GH pulse amplitude which will result in decreased GH tissue stimulation.

Using CJC 1295 Safely

It is recommended when using a long-acting CJC molecule to have 'hormone holidays' of three months each three to six months, to allow the pituitary to 'recover'. During the holidays, Sermorelin is used instead of CJC 1295 + DAC.

The 'hormone holidays' may also minimize the risk of GH resistance developing. This resistance, or insensitivity, may occur via antibodies forming that bind to and inactivate GH, or by a decreased number of GH receptors on tissues (down-regulation). These are theoretical concerns as no long-term studies have been undertaken to clarify the issues.

Side effects of CJC-1295 may include injection site reactions (irritation, erythema, induration, pain, itching), headache, diarrhea, vasodilation (flushing, warmth, transient hypotension), nausea, abdominal pain.

CJC-1295 DAC Peptide Ancillary Studies

In 2005, a study began to evaluate the mechanism of action of CJC-1295 in subjects with immunodeficiency virus (HIV) associated with visceral obesity. In this study, the subjects would be presented with CJC-1295 for 3 months and followed by a 6 week follow-up period. However, this study was terminated during the recruitment process, and no related results were posted.

According to a Norwegian study, in 2009 a compound was submitted for analysis to evaluate whether it contained prohibited substances or not. The researchers of the Norwegian Doping Control Laboratory and School of Pharmacy reported that this substance was CJC-1295. In their published article they concluded that "CJC-1295 is a releasing factor for growth hormone".

Does CJC-1295 with DAC work?

CJC-1295 with DAC (Drug Affinity Complex) is a synthetic peptide used in some fitness and bodybuilding circles. It is often touted for its potential to stimulate the release of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) in the body, which are hormones that can have anabolic effects, including muscle growth and fat loss.

Here's how CJC-1295 with DAC is believed to work:

Stimulating GH Release: CJC-1295 is a growth hormone-releasing hormone (GHRH) analog. It works by mimicking the action of GHRH, which is a natural hormone that stimulates the pituitary gland to release growth hormone. By using CJC-1295 with DAC, some individuals hope to increase their GH levels.

Prolonged Half-Life: The addition of DAC to CJC-1295 is intended to extend its half-life, meaning that it remains active in the body for a longer duration. This allows for more sustained stimulation of GH release.

While some users have reported positive effects when using CJC-1295 with DAC, it's important to note the following considerations:

Lack of Regulation: Peptides like CJC-1295 with DAC are often sold as research chemicals or for "experimental" use, and they are not approved by regulatory agencies like the FDA for human consumption. As a result, their safety and effectiveness are not well-studied or regulated.

Variable Results: The effects of CJC-1295 with DAC can vary widely among individuals. Not everyone will respond the same way, and some users may not experience the desired results.

Potential Side Effects: Like all substances that affect hormone levels, there can be potential side effects or risks associated with the use of CJC-1295 with DAC. These may include hormonal imbalances, water retention, joint pain, and more.

Before considering the use of CJC-1295 with DAC or any other peptide or hormone-modulating substance, it is crucial to consult with a healthcare professional who is knowledgeable about such substances. They can provide guidance, monitor your health, and help you make informed decisions about your fitness and supplementation regimen.

Furthermore, it's important to prioritize safe and evidence-based approaches to fitness and bodybuilding, including proper nutrition, regular exercise, and, when needed, guidance from qualified fitness and healthcare experts.

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