CJC1295 With DAC CAS: 446262-90-4

Description

CJC-1295 is a synthetic GHRH (growth hormone releasing hormone) analogue made up of 30 amino acids. It has been found to be highly effective with regards to the increase of growth hormone secretion and IGF-1 without negatively affecting the pulsatility of GH secretion.

CJC-1295 is often combined with Ipamorelin due to its enhanced specificity as a GHRH. This peptide generates similar increases in growth hormone secretion, but without the appetite stimulation and increase in cortisol, acetylcholine, prolactin, and aldosterone seen with other peptides in its class. This peptide has been found to be very well-tolerated and perfect when combined with Ipamorelin.

Clinical data

What is CJC-1295 + DAC?

Several studies involving CJC-1295 + DAC have shown promising results regarding the increase of hGH (human Growth Hormone) in both men and women. The results were so good in fact that CJC-1295 + DAC is pretty much the equivalent to Modified GRF 1-29. Here are some of the findings of the studies involving CJC-1295 + DAC, so that you can judge for yourself.

CJC-1295 + DAC study conducted in 2004, involved men and also produced similar results to Modified GRF 1-29. There was a 200% increase in the IGF-1 and hGH levels, So not only does it increase the hGH level, it also increases the substrate required for the anabolic reactions to occur. Which basically means that more hGH can be utilized, which means muscle hypertrophy occurs faster, all that happened while abdominal fat was reduced.

And Another Study.

Based on a 2006 CJC-1295 + DAC study, the peptide showed its potential as a long-term simulator of both the IGF-1 and hGH levels. The study indicated an increase in hGH anywhere from 200% up to 1000%, and this after a single daily injection for six days. Remember CJC-1295 + DAC half-life is extremely long consequently the hGH level remained higher than normal for up to a month in healthy test subjects aged between 21 and 61.

Knowing that this peptide has a long half-life, which eliminates the threat of food interactions that might reduce its efficacy, making it a convenient alternative to Modified GRF 1-29. Clinical studies in which CJC-1295 + DAC have been used claimed the peptide's effectiveness, but experts do not recommend using this peptide for more than 6 months without taking some time off to avoid damaging the pituitary gland. These peptides have been used in the scientific field for quite many years now and are relatively safe.

Mechanism of Action

The DAC component is a biochemical complex thought to further prolong the half-life of the peptide. This enhancement is attributed to the DAC's potential to bind to plasma proteins. Specifically, the DAC component involves attaching a lysine derivative, N-epsilon-3-maleimidopropionamide, to the C-terminus of CJC-1295 DAC. The integration of this modified amino acid sequence with the DAC component may support the pharmacokinetics of CJC-1295 DAC, potentially extending its half-life to approximately 8 days. Concurrently, it maintains a significant affinity for GHRH receptors, similar to the affinity of CJC-1295 without DAC.⁽²⁾

CJC-1295 without DAC also holds relevance in contemporary research. For instance, the combination of CJC-1295 without DAC and Ipamorelin has been studied for its synergistic potential. This blend of GHRH analogs with peptides that seemingly activate ghrelin receptors in the pituitary gland is posited to induce a more substantial GH synthesis response from somatotroph cells.⁽³⁾

CJC-1295 DAC Peptide Half-life

In its original form, CJC-1295 uses a technology referred to as Drug Affinity Complex (DAC). Contrary to the GHRH which has a half-life of approximately 7 minutes, CJC-1295 is reported by researchers to exhibit a longer half-life of 6-8 days due to the DAC technology.

CJC-1295 DAC Peptide Ancillary Studies

In 2005, a study began to evaluate the mechanism of action of CJC-1295 in subjects with immunodeficiency virus (HIV) associated with visceral obesity. In this study, the subjects would be presented with CJC-1295 for 3 months and followed by a 6 week follow-up period. However, this study was terminated during the recruitment process, and no related results were posted.

According to a Norwegian study, in 2009 a compound was submitted for analysis to evaluate whether it contained prohibited substances or not. The researchers of the Norwegian Doping Control Laboratory and School of Pharmacy reported that this substance was CJC-1295. In their published article they concluded that "CJC-1295 is a releasing factor for growth hormone".

How Does CJC-1295 Work?

I strongly believe that you should know the working mechanism of the peptide before really using it. With CJC-1295, it's an easy one to grasp.

CJC-1295, an analog of GHRH, binds to the receptors on the anterior pituitary gland. From there, they stimulate the release of Growth Hormone (GH) and Insulin-like growth factor-1 (IGF-1) (3).

Research suggests a very similar mechanism of action associated with Sermorelin. However, unlike Sermorelin, which causes a more pulsatile release of Growth Hormone, CJC-1295 triggers a more drastic release.

Experiments have revealed that CJC-1295 can cause a 200-1000% increase in the body's GH levels. Importantly, the levels remain up for more than 6 days, thus inducing pronounced effects overall.

Does CJC-1295 with DAC work?

CJC-1295 with DAC (Drug Affinity Complex) is a synthetic peptide used in some fitness and bodybuilding circles. It is often touted for its potential to stimulate the release of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) in the body, which are hormones that can have anabolic effects, including muscle growth and fat loss.

Here's how CJC-1295 with DAC is believed to work:

Stimulating GH Release: CJC-1295 is a growth hormone-releasing hormone (GHRH) analog. It works by mimicking the action of GHRH, which is a natural hormone that stimulates the pituitary gland to release growth hormone. By using CJC-1295 with DAC, some individuals hope to increase their GH levels.

Prolonged Half-Life: The addition of DAC to CJC-1295 is intended to extend its half-life, meaning that it remains active in the body for a longer duration. This allows for more sustained stimulation of GH release.

While some users have reported positive effects when using CJC-1295 with DAC, it's important to note the following considerations:

Lack of Regulation: Peptides like CJC-1295 with DAC are often sold as research chemicals or for "experimental" use, and they are not approved by regulatory agencies like the FDA for human consumption. As a result, their safety and effectiveness are not well-studied or regulated.

Variable Results: The effects of CJC-1295 with DAC can vary widely among individuals. Not everyone will respond the same way, and some users may not experience the desired results.

Potential Side Effects: Like all substances that affect hormone levels, there can be potential side effects or risks associated with the use of CJC-1295 with DAC. These may include hormonal imbalances, water retention, joint pain, and more.

Before considering the use of CJC-1295 with DAC or any other peptide or hormone-modulating substance, it is crucial to consult with a healthcare professional who is knowledgeable about such substances. They can provide guidance, monitor your health, and help you make informed decisions about your fitness and supplementation regimen.

Furthermore, it's important to prioritize safe and evidence-based approaches to fitness and bodybuilding, including proper nutrition, regular exercise, and, when needed, guidance from qualified fitness and healthcare experts.

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