A. Metabolic Modulation
●Appetite Suppression: GLP-1 and GIP activation reduce hunger signaling in the hypothalamus, aiding calorie restriction.
●Lipolytic Effects: Glucagon receptor agonism stimulates lipolysis, mobilizing stored fat for energy.
●Insulin Sensitivity Enhancement: Improves glucose uptake in muscles, reducing fat storage.
B. Muscle Preservation
●Anti-Catabolic Signaling: Glucagon receptors in skeletal muscle may inhibit proteolysis during cutting phases.
●Amino Acid Sparing: Enhanced glycogenolysis spares amino acids from gluconeogenesis, preserving lean mass.
C. Sustained Action
●Extended Half-Life: ~120 hours (5 days) due to albumin-binding modifications, enabling weekly dosing.
●Stable Plasma Levels: Reduces peaks/troughs linked to side effects like nausea.
