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Description
Metribolone, also known as R-1881, is a highly potent synthetic androgen commonly used as a reference compound in androgen receptor research. Due to its exceptionally strong binding affinity to the androgen receptor, it is widely utilized in laboratory and in vitro studies where precise and stable androgenic activity is required.



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What is Metribolone?
●Core Identity: Methyltrienolone is a 17α-alkylated (methylated) derivative of the potent progestin/nandrolone analogue, trenbolone. Specifically, it's 17α-methyl-δ9,11-estrenolone.
●Structural Power: Its potency arises from key modifications:
○19-Nor Structure: Removal of the carbon-19 methyl group (like nandrolone or trenbolone) reduces estrogenic conversion and alters androgen receptor (AR) interaction.
○Double Bonds (Δ9,11): These prevent aromatization to estrogen and significantly increase binding affinity to the androgen receptor, surpassing even dihydrotestosterone (DHT).
○17α-Methylation: This crucial modification allows oral bioavailability by resisting first-pass liver metabolism. However, this is the primary source of its extreme hepatotoxicity.
●Form: As a powder, Methyltrienolone is the raw crystalline form of the hormone. This form is primarily used in research settings or illicitly by underground labs (UGLs) to formulate oral capsules, tablets, or (highly inadvisably) injectable solutions. It is not intended for human consumption.
Clinical Data
Trade names Agoviron, Android, Metandren, Oraviron, Oreton, Testovis, Testred, Virilon,
RU-24400; NSC-9701; 17α-Methyltestosterone; 17α-Methylandrost-4-en-17β-ol-3-one
CAS
58-18-4 Molar mass
302.458 Formula C20H30O2 Purity
Above 98%
Apprarance
White crystalline powder
Advantages
Strong and consistent receptor interaction
Clear androgenic profile without estrogenic pathways
Suitable for advanced androgen-related research
Widely recognized reference compound in scientific studies
Key Characteristics
Extremely high androgen receptor binding affinity
Non-aromatizing compound
Not reduced by 5-alpha reductase
Stable molecular structure
Active at very low concentrations in research settings
Research Applications
Androgen receptor binding studies
Hormone signaling pathway research
Comparative analysis of androgenic activity
Reference standard in laboratory experiments
Physical Stability & Storage Requirements
Store in a cool, dry place
Protect from heat, light, and moisture
Keep container tightly sealed
Stable under recommended storage conditions
Dosage and Administration
●Dosage: There is NO Safe Dose. Illicit use typically involves doses ranging from 250 mcg (0.25mg) to 1000 mcg (1mg) per day, sometimes split into multiple doses. Even doses as low as 0.5mg/day have caused severe liver toxicity requiring hospitalization within weeks. Microgram scales are essential but offer no safety guarantee.
●Cycle Length: Extremely Short Duration is Mandatory (But Still Unsafe). If used illicitly despite the risks, cycles are rarely advised beyond 2-4 weeks due to the rapid onset of hepatotoxicity. Many report significant side effects within the first 1-2 weeks. Longer use exponentially increases the risk of catastrophic damage.
●Half-Life: Methyltrienolone has a very short half-life, estimated to be approximately 4-6 hours in humans. This necessitates dosing 2-4 times per day to maintain stable blood levels, further increasing the burden on the liver and making consistent dosing challenging. Its metabolites may persist longer, contributing to prolonged toxic effects.
●Administration: Primarily oral (capsules/tablets). Injectable forms exist but are highly discouraged due to even faster absorption and potentially accelerated toxicity. The powder form itself is NOT for direct human consumption.
Conclusion
Methyltrienolone raw material powder is the apotheosis of anabolic potency-a compound that exists at the furthest extreme of the risk-reward spectrum. It is a tool that can chisel a physique into its ultimate, grainy, and conditioned form but does so by wielding a toxic hammer against the user's own biology.
Its application is so niche that it borders on obscurity, reserved for a tiny fraction of the competitive bodybuilding elite who are willing to gamble short-term health for a competitive edge. For the overwhelming majority of athletes, even experienced ones, the risks associated with Metribolone catastrophically outweigh any potential benefit. The existence of other, less toxic compounds that can achieve similar goals (e.g., Masteron, Oral Turinabol, Anavar) makes the choice to use Methyltrienolone one of the most consequential and dangerous decisions in all of performance enhancement. It stands as a stark reminder of the extreme lengths pursued in the sport and the profound physiological cost that often accompanies it.
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Any needs, please contact me
Email: amyraws195@gmail.com
Whatsapp/Telegram: +852 56445864


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