Exemestane(Aromasin) CAS:107868-30-4

Description

Exemestane, sold under the brand name Aromasin among others, is a medication used to treat breast cancer. It is a member of the class of antiestrogens known as aromatase inhibitors. Some breast cancers require estrogen to grow. Those cancers have estrogen receptors (ERs), and are called ER-positive. They may also be called estrogen-responsive, hormonally-responsive, or hormone-receptor-positive. Aromatase is an enzyme that synthesizes estrogen. Aromatase inhibitors block the synthesis of estrogen. This lowers the estrogen level, and slows the growth of cancers.

Many breast cancers are stimulated to grow by the female sex hormones oestrogen and progesterone. These breast cancers are called hormone sensitive or hormone receptor positive. Blocking the effects of these hormones can treat breast cancer.

In women who have had their menopause, oestrogen is mainly produced by changing androgens (sex hormones produced by the adrenal glands) into oestrogens. This process is called aromatisation and happens mainly in the fatty tissues, muscle and skin. It needs a particular enzyme called aromatase.

Exemestane blocks the process of aromatisation. So it lowers the amount of oestrogen in the body. In early breast cancer, taking exemestane can help to stop breast cancer coming back. In advanced breast cancer, the cancer cells may grow more slowly or stop growing completely.

Clinical Data

Aromasin Medical Uses

This aromatase inhibitor is indicated for

the treatment of advanced breast cancer in breast cancer in women who no longer have their menstrual periods, either naturally due to their age (after menopause) or because they have had their ovaries surgically removed.

risk reduction for invasive breast cancer in postmenopausal women.

Mechanism of action

In premenopausal women, ovaries are the main sources of estrogen but converted estrogen by the aromatase enzyme in the peripheral tissue and some parts of the brain is the source of estrogen in post-menopausal women. Exemestane is acted as an intermediate and binds to the active site of the enzyme. This binding leads to inactivation known as " suicide inhibition". This medication is structurally similar to the enzyme targets; si it permanently binds to the enzyme, preventing them from converting androgen into estrogen.

What Are The Benefits Of Exemestane?

When a user takes the recommended dose of Exemestane, it will provide various benefits such as:

●Accelerate the secretion of insulin-like growth factor

●Lower androgenic activities

●Quickly restore the process of testosterone synthesis

●Increase concentration of IGF factor

●Protect muscle tissue from destruction

●It balances anabolism and catabolism of users

●It prevents steroids users from estrogenic side effects (such as gynecomastia, water and fluid retention and bloating)

●Suppress female hormones

●Improve muscles relief

●Promote anabolic background growth

●It prevents users from hypertension

●Reduce the adverse effects of estrogen on the pituitary gland

●All the benefits users can get when they use high-quality products. Always buy Exemestane from the top resources. The internet makes it easier to find Exemestane for sale.

What are the main differences between Arimidex and Aromasin?

Arimidex is the brand name for anastrozole. It was FDA approved in 1995, and it is used to treat hormone receptor-positive receptor early breast cancer in postmenopausal women. Arimidex is available as a 1 mg tablet taken once daily with or without food. The absorption of Arimidex in the body is not greatly affected by food. Arimidex is manufactured by ANI Pharmaceuticals.

Aromasin is the brand name for exemestane. It was FDA approved in 1999, and it is used to treat hormone receptor-positive receptor early breast cancer in postmenopausal women who have already used tamoxifen for two to three years. Aromasin is available as a 25 mg tablet taken once daily after a meal. Food has been shown to help increase the absorption of Aromasin by the body. Aromasin is manufactured by Pfizer.

Is Arimidex or Aromasin more effective?

Arimidex and Aromasin are effective breast cancer treatments. The most effective breast cancer treatment will depend on a number of factors such as the individual's response to the treatment, any side effects experienced, and the cost of treatment. A healthcare provider should be consulted to determine the best option.

Anastrozole and exemestane, the active ingredients in Arimidex and Aromasin, respectively, have been compared in head-to-head clinical trials. One study published in The Lancet Oncology compared anastrozole, exemestane, and letrozole. The study found that these aromatase inhibitors were similarly effective for treating hormone receptor-positive breast cancer. The study also found that five years of aromatase inhibitor therapy was not superior to two years of tamoxifen therapy followed by the use of an aromatase inhibitor for three years.

Another study published in the Journal of Clinical Oncology found that both aromatase inhibitors are similarly effective as adjuvant treatments for postmenopausal breast cancer. The main deciding factor between aromatase inhibitors may be the tolerability of the drugs regarding potential side effects. The same study found that exemestane could be an option for up-front adjuvant therapy for postmenopausal hormone receptor-positive breast cancer without the need for two to three years of tamoxifen treatment first.

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