Anabolic Powder Anastrozole (arimidex) CAS:120511-73-1 With Good Price

Anabolic Powder Anastrozole (arimidex) CAS:120511-73-1 With Good Price

Product Name: Anastrozole
CAS: 120511-73-1
MF: C17H19N5
MW: 293.37
Purity: 99%
Appearance: White Powder
High Light: Anastrozole, Arimidex, CAS 120511-73-1

Product Introduction

COA:

 

Items Standard Results
Description White crystalline powder Complies
Identification

IR

HPLC

Reactive

Conform with standard IR

Conform with standard HPLC

Conform

Solubility Freely soluble in methanol,acetone,ethanol and tetrahydrofuran.And very soluble in acetonitrile Complies
Total Impurity max.0.5% 0.18%
Total Unspecified Impurity max. 0.2% 0.08%
Individual unspecified impurlty max. 0.1% 0.05%
Related compound B max. 0.2% 0.07%
Related compound C max. 0.2% 0.04%
Related compound D max. 0.1% 0.05%
Related compound E max. 0.1% 0.06%
Limit of cyclohexane max. 0.08% ND
Limit of ethylacetate max. 0.1% 0.07%
Melting point 81.0~84.0℃ 82.5~83.2℃
Water max. 0.3% 0.21%
Residue on ignition max. 0.1% 0.07%
Heavy Metals max.0.001% Complies
Assay(HPLC) 98.0%~102.0% 99.8%
Storage Cool and dry
Conclusion It complies to USP32 .

 

Description:

Anastrozole is a medication primarily used to treat certain types of breast cancer in postmenopausal women. It belongs to a class of drugs called aromatase inhibitors, which work by inhibiting the enzyme aromatase. Aromatase is responsible for converting androgens (such as testosterone) into estrogen, a hormone that can promote the growth of certain breast cancers. By inhibiting aromatase, anastrozole helps reduce estrogen levels in the body, thus slowing down or stopping the growth of hormone receptor-positive breast tumors.

Breast Cancer Treatment: Anastrozole is commonly prescribed as adjuvant therapy or as initial treatment for postmenopausal women with hormone receptor-positive breast cancer. It may be used alone or in combination with other treatments, such as surgery or radiation therapy. Aromatase Inhibitor: Anastrozole belongs to a class of drugs known as aromatase inhibitors. It specifically inhibits the aromatase enzyme, which plays a crucial role in the production of estrogen from androgens in postmenopausal women. Estrogen Reduction: By reducing estrogen levels, anastrozole helps to slow down or stop the growth of hormone receptor-positive breast tumors. It can also prevent the recurrence of breast cancer in women who have completed their initial treatment. Postmenopausal Women: Anastrozole is generally prescribed to postmenopausal women because aromatase inhibitors are most effective in this population. This is because postmenopausal women have lower levels of endogenous estrogen compared to premenopausal women. Side Effects: Common side effects of anastrozole may include hot flashes, joint pain or stiffness, fatigue, nausea, bone thinning (osteoporosis), and increased risk of fractures. It may also cause changes in lipid profiles, leading to increased cholesterol levels. Rare but serious side effects may include allergic reactions, liver problems, and cardiovascular events. Duration of Treatment: The duration of anastrozole treatment varies depending on the specific circumstances and the stage of breast cancer. It is usually prescribed for a period of five to ten years, but this can be determined by the patient's oncologist based on individual factors and treatment response. Hormone Replacement Therapy (HRT): Anastrozole is not used as a form of hormone replacement therapy (HRT) for menopausal symptoms. Its role is specifically targeted towards the treatment of hormone receptor-positive breast cancer and not to alleviate menopause-related symptoms.

 

Is anastrozole vs tamoxifen?

Anastrozole and tamoxifen are both medications commonly used in the treatment of hormone receptor-positive breast cancer. However, they belong to different classes of drugs and work in different ways. Anastrozole is an aromatase inhibitor, which means it works by reducing the production of estrogen in postmenopausal women. Estrogen can stimulate the growth of hormone receptor-positive breast cancer cells. By inhibiting the production of estrogen, anastrozole helps to slow down the growth of these cancer cells. Tamoxifen, on the other hand, is a selective estrogen receptor modulator (SERM). It blocks the estrogen receptors in breast cells, preventing estrogen from binding to these receptors and promoting the growth of cancer cells. Tamoxifen is used in both premenopausal and postmenopausal women with hormone receptor-positive breast cancer. The choice between anastrozole and tamoxifen depends on various factors, including menopausal status and the specific characteristics of the breast cancer. In general, anastrozole is typically recommended as the initial treatment for postmenopausal women, while tamoxifen may be used as a first-line therapy for premenopausal women or in certain cases where anastrozole is not suitable.

 

Is anastrozole a good estrogen blocker?

anastrozole is an effective estrogen blocker. It is classified as an aromatase inhibitor, which means it inhibits the enzyme aromatase, responsible for converting androgens (male hormones) into estrogens (female hormones), primarily in postmenopausal women. By reducing estrogen production, anastrozole effectively lowers the levels of estrogen in the body. Anastrozole is commonly prescribed to postmenopausal women with hormone receptor-positive breast cancer to help prevent the recurrence of the disease. It has been shown to be more effective than tamoxifen in reducing the risk of recurrence in postmenopausal women. In addition to breast cancer treatment, anastrozole is also used to treat other hormone-related conditions, such as infertility in women with anovulation. However, it's important to note that anastrozole is not suitable for everyone, and its use should be determined by a healthcare professional based on individual factors and considerations. Side effects and contraindications may exist, and regular monitoring is necessary during treatment.

 


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