Peptides Powder CJC1295 With DAC

Description

CJC1295 with DAC (Drug Affinity Complex) is a synthetic peptide engineered to enhance growth hormone (GH) secretion. Unlike traditional GH-releasing peptides (GHRPs), CJC1295 with DAC offers a prolonged half-life due to its unique molecular structure, making it a staple in modern bodybuilding regimens. This peptide binds to albumin in the bloodstream, delaying degradation and sustaining GH release for days. Its ability to amplify muscle growth, accelerate fat loss, and improve recovery has positioned it as a game-changer in performance enhancement.

Basic Product Information

What Is CJC-1295 with DAC?

CJC-1295 is a synthetic analog of Growth Hormone–Releasing Hormone (GHRH). 

The "DAC" stands for Drug Affinity Complex, which is a modification that allows the peptide to bind to serum albumin. Peptide Science+2Synergen Peptides+2

This binding dramatically extends its half-life, making its duration of action much longer than unmodified GHRH analogs. Peptide Protocols+2Peptides.org+2

Reported half-life for CJC-1295 with DAC is roughly 6–8 days.

Mechanism of Action

GHRH Receptor Activation

CJC-1295 with DAC binds to GHRH receptors in the anterior pituitary. Peptide Initiative+2Synergen Peptides+2

This triggers intracellular signaling (cAMP → PKA) that leads to growth hormone (GH) release. NextGenPeps+1

Prolonged GH Stimulation

Thanks to the DAC modification, CJC-1295 remains in circulation longer, providing sustained stimulation of GH rather than a short pulse. Peptides.org

Because of albumin binding, the peptide is protected from rapid degradation. Peptide Science+1

IGF-1 Production

Increased GH release stimulates the liver (and possibly other tissues) to produce Insulin-like Growth Factor 1 (IGF-1), which has anabolic and regenerative effects.

Research Applications & Benefits

In scientific / research settings, CJC-1295 with DAC is used for:

GH Axis Research: Studying the dynamics of growth hormone release, feedback mechanisms, and long-term GH stimulation. 

Anabolism & Tissue Regeneration: Exploring its effects on muscle growth, protein synthesis, and recovery. 

IGF-1–Mediated Effects: Research into how sustained IGF-1 elevation may influence metabolism, fat loss, bone health, and other regenerative processes. 

Therapeutic & Anti-Aging Research: Some clinics and research groups consider it for long-term GH support, anti-aging, or recovery, due to its prolonged activity.

Advantages & Trade-offs

Advantages:

Less Frequent Dosing: Because of its long half-life, injections may be needed only once or twice per week. 

Stable GH Elevation: Provides a more sustained GH release compared to short-lived peptides. 

Efficient IGF-1 Stimulation: Extended GH presence can drive longer-lasting IGF-1 increases. 

Potential Trade-offs / Risks (based on research and anecdotal reports):

Because GH stimulation is prolonged, there's a risk of constant or non-physiological GH elevation, which could lead to receptor desensitization or other downstream issues. 

Some users/observers report side effects like water retention, flushing, or tingling, which may be more pronounced due to prolonged exposure. 

The DAC part involves a maleimide linker, which in theory could react with proteins in other parts of the body, though real-world long-term safety is not fully established in clinical settings.

CJC-1295 Dosage Calculator

Concerning CJC-1295 dosage, researchers may refer to the two 2006 studies by Teichman et al., which involved healthy test subjects aged 21-61 and followed a randomized, placebo-controlled, double-blind, ascending dose design .

In the first study, which lasted 28 days, CJC-1295 or placebo was administered in one of four ascending single doses.

In the second study, which lasted 49 days, test subjects received CJC-1295 or placebo in two or three weekly or biweekly doses.

After measuring the peak concentrations and area under the curve of GH and IGF-1, researchers found that CJC-1295 increased mean plasma GH concentrations by 2- to 10-fold for 6 days or more, and increased mean plasma IGF-I concentrations by 1.5- to 3-fold for 9-11 days.

Studies suggest that CJC-1295 boosts GH and IGF-I levels in healthy adults and is tolerated in a dose range of 30-60 μg/kg

Important Notices

Storage: Lyophilized (powder) form typically needs to be stored at low temperature (e.g., –20 °C), and once reconstituted, stored properly to maintain stability. 

Quality Matters: Because of its long action, impurities or degradation products could have amplified effects over time - using high-quality, verified research-grade peptide is essential.

Not a Replacement for GH Therapy: While it can stimulate GH release, it does not fully replicate the safety, regulation, or control of medically supervised GH therapy.

Our Advantages

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