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Description
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Sermorelin is a synthetic peptide derived from an endogenous hormone called growth hormone-releasing hormone (GHRH). Similar to GHRH, sermorelin exerts its effects in the pituitary gland by binding to somatotroph cells leading to secretion of growth hormone.
The peptide was previously approved by the United States Food and Drug Administration (FDA) for treatment of short stature disorder, proving to be safe and effective at inducing catch-up growth in undersized children through increasing GH and insulin-like growth factor 1 (IGF-1).
Similarly, human trials have demonstrated that sermorelin can safely increase GH and IGF-1 levels in healthy older adults, leading to fat loss and increased lean body mass.
Sermorelin and related GH-releasing peptides are the subject of research interest based on claims that they can deliver several highly sought-after anti-aging effects associated with increased GH such as improved body composition, thicker skin, improved well-being, and libido.
When is sermorelin used?
Sermorelin is used to diagnose and treat poor growth in children. It's also sometimes used off-labelTrusted Source to treat hGH deficiency in adults. Some researchTrusted Source has suggested that it can be beneficial in people with certain recurrent brain tumors.
Children usually benefit the most from sermorelin. One older study reported that a daily injection of sermorelin increased growth rate in 74 percent of children after just 6 months.
Studies investigating benefits of sermorelin in adults are scarce, but researchers have observedTrusted Source that sermorelin injection increases hGH levels in the bloodstream.
These findings have led to widespread claims that sermorelin is an anti-aging therapy that can restore your body's natural hGH production. Indeed, some older research suggests that sermorelin may increase:
general well-being
lean body mass
insulin sensitivity
libido
However, definitive research to support the anti-aging effect of sermorelin is lacking. The use of sermorelin in healthy adults to reverse the effects of aging and in bodybuilding remains controversial.
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What Does Sermorelin Do?
Sermorelin is a 29-amino acid peptide derivative of the endogenous peptide hormone GHRH, that retains the full functional activity of GHRH, due to the fact that the sermorelin peptide includes the GHRH receptor binding domain.
Sermorelin has a rapid half life of 11-12 minutes when administered via injection and exerts its effects by binding to the GHRH receptor at the pituitary gland. This leads to stimulation of growth hormone secretion by the pituitary gland, independent of changes to other hormones such as luteinizing hormone (LH), follicle-stimulating hormone (FHS), prolactin, cortisol, glucose, glucagon, or thyroid stimulating hormone (TSH).
Unlike administration of GH which introduces an unnatural, single bolus of the hormone, sermorelin leads to stimulation of pulsatile GH secretion that mirrors endogenous secretion patterns . It is hypothesized that GH secretion in this pulsatile fashion over a 24-hour period is important for reaping the full benefits of the GH-IGF-1 axis.
An important byproduct of sermorelin's targeting of the underlying regulatory feedback pathway is that GH and IGF-1 levels are maintained in a physiological range, avoiding the negative consequences of GH therapy.
Similar to hGH administration, the most notable effects of sermorelin are around increased lipolysis due to direct action of GH on adipose tissue and increased lean body mass due to upregulation of IGF-1 secretion.
Due to these unique properties, sermorelin is useful to researchers interested in an alternative to exogenous rhGH administration that can produce the following effects, all otherwise associated with rhGH:
• Diagnosis of growth hormone deficiency
• Treatment of low IGF-1 levels
• Improvements in body composition and fat loss
• Improved muscle strength and exercise performance
• Increased skin thickness
• Improved memory and well-being
• Increased resting energy expenditure
Sermorelin Dosage And Cycle
Sermorelin has been administered at a relatively wide range of doses in various human clinical trials via both intravenous (IV) and subcutaneous (sc) injection
As we have noted, sermorelin's mechanism of action leverages the natural GH secretion pathway with resulting GH levels maintained within a physiological range by the natural regulatory machinery .
As a result, the peptide is unique in that increasing sermorelin dosages above a certain level does not result in increased effects on GH and IGF-1. Nonetheless, we recommend that researchers use a conservative dosing protocol and use the minimal therapeutic dose.
A hypothetical dosing protocol to help researchers understand how sermorelin might be dosed in a potential trial is as follows:
• Tolerance assessment: To assess tolerance, begin with a dose of 100mcg injected subcutaneously. (Note that 1mg is equal to 1000mcg, and 100mcg is equal to 1/10th of a milligram)
• Low-dose protocol (200mcg/day): Since sermorelin has a short half-life, administer 100mcg via sc injection in the morning and again in the evening before bed, for a total of 200mcg.
• High-dose protocol (600mcg/day): For users who do not respond to the low dose protocol, administer 200mcg of sermorelin in the morning, afternoon, and prior to bedtime for a total of 600mcg.
The most useful biomarker for understanding whether sermorelin is having an effect at a given dosage is IGF-1. Therefore, to best assess the effects of a particular dose of sermorelin, we recommend that researchers get baseline blood work with follow-up bloodwork after at least 2 weeks at a given dosing protocol.
Based on the available literature, sermorelin does not appear to require cycling and has been administered in trials for up to 36 months of continuous usage.
Note that sermorelin peptide will be lyophilized into a freeze-dried powder after manufacturing to improve temperature stability and increase shelf life. Prior to injection, researchers will need to use bacteriostatic water to reconstitute and dissolve the freeze-dried peptide into an injectable liquid solution.
Who should avoid sermorelin
People with certain medical conditions may require additional screening before taking sermorelin and sometimes should avoid this therapy. These conditions include:
people who are allergic to sermorelin
people with untreated hypothyroidism
women who are pregnant or are planning to become pregnant
women who are breastfeeding
How is sermorelin administered?
You don't need to visit a doctor's office for sermorelin injections. Instead, you can self-administer injections at home. Sermorelin is injected subcutaneously, which means under the skin.
To prevent contamination, wipe the rubber vial stopper with an antiseptic before puncturing it with the needle. When injecting, target the fatty tissue just below the skin. Many people inject their stomach or thigh.
To avoid bruising and soreness, it's best to switch up the location of the injection site. Ask your doctor to show you the best injection technique.
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