Adipotide CAS:859216-15-2

Description

Adipotide, referred to also as FTPP, is an experimental weight loss treatment that's been proven to kill fat cells by starving them of blood supply, so that they die and are reabsorbed into the body, as research on animals showed.

Established in 2011 by Dr. Wadih Arap and Renata Pasqualini, FTPP peptide is considered to be a diet and cancer pill.

According to research, adipotide is a new and innovative drug that is showing great promise in the area of obesity research. Initially created as cancer treated with the purpose of targeting cancer cells so that they would stop growing, Adipotide peptide has also shown promise of decreasing body weight, as studies in animals showed.

Adipotide is a peptidomimetic substance with a structural sequence of CKGGRAKDC-GG-D(KLAKLAK)2. Adipotide selectively acts and shrinks the adipose tissue fat supplying blood vessels and induce apoptosis. In primates and rodents, Adipotide significantly induce weight loss by rapid fat elimination. The compound directly acts on fat cells due to high affinity towards two receptors such as prohibitin and ANXA2.

Clinical data

Principle of action

Clinical studies reveal that adipotide is able to cause adipocytes apoptosis, which in turn causes reduction in mass, and volume and mass of the subcutaneous fat. The hormone causes a programmed cell death by depriving them nutrients and this cause cellular atrophy. Moreover in the mitochondrial cascade to increase the production of proteins from the amino acids while reducing fat cells.

Research shows that the adipotide kills fat cells by selectively causing a programmed cell death or apoptosis. When the fat cells are deprived of nutrients, they die of starvation and causing the release of the enzymes referred to as caspases in which are the enzymes that initiate programmed cell death. Adipotide acts on ANXA-2 and prohibitin receptors, these are cell surface receptors located in the endothelial wall and the vessels supply blood to white adipocytes. The formation of white adipocytes often occurs when the energy consumption is less than utilization, this leads to the conversion of the excess energy to fats for storage. Obesity is a key aspect in development of a myriad of diseases such as myocardial infarctions and degenerative diseases. Abdominal obesity is often associated with white adipocytes.

what is adipotide used for?

Adipotide is an experimental peptide-based drug that has been studied primarily in animal models, particularly in non-human primates, for its potential use in the treatment of obesity. Its main mechanism of action involves targeting and destroying fat cells (adipocytes) in the body, resulting in a reduction of fat mass and weight loss. Specifically, Adipotide binds to a protein called prohibitin found on the surface of fat cells, leading to programmed cell death, or apoptosis, in those cells.

Key points about the potential use of Adipotide:

Obesity Treatment: Adipotide has been investigated as a potential treatment for obesity. By selectively reducing fat mass, it aims to address one of the underlying factors contributing to obesity-related health issues.

Fat Reduction: The drug is designed to target and destroy fat cells, leading to a decrease in body fat. Animal studies, particularly in monkeys, have shown significant reductions in fat mass and weight.

Preclinical Research: Most of the research on Adipotide has been conducted in animal models. Human trials were limited, and the drug had not received regulatory approval for use in humans in most countries as of my last knowledge update in September 2021.

Potential Side Effects: Adipotide has been associated with side effects in animal studies, including kidney damage and electrolyte imbalances. Safety concerns and the need for further research are important considerations.

It's essential to understand that the development and approval of new drugs, especially those for conditions like obesity, require extensive clinical testing to assess safety and efficacy in humans. Additionally, potential side effects and long-term effects need to be thoroughly evaluated.

If you are interested in addressing obesity or weight management, it is strongly recommended that you consult with a healthcare professional who can provide guidance on safe and effective approaches to achieve your goals. Weight management typically involves a combination of a healthy diet, regular physical activity, behavioral changes, and medical interventions when appropriate, all under the supervision of qualified healthcare providers.

Adipotide Peptide and Obesity

"Setback of obesity by targeted ablation of adipose tissue" was the title of a 2004 research by Mikhail G. Kolonin et al., in a peer-reviewed academic publication that published the study's results. This research aimed to clarify that white adipose tissue vascular bed-focused vascular apoptosis induction may be a potentially effective anti-obesity procedure. In this experiment, mice served as the subjects.

Adipotide Peptide and Weight

An excess of adipose tissue bulk causes obesity. White adipose tissue is the primary culprit of obesity, according to studies. Since a rise in weight may be attributable to other causes than an increase in adiposity, it is important to note that a rise in body weight alone does not constitute obesity. An increase in mortality and morbidity rates is linked to obesity. The current methods for determining obesity include densitometry, anthropometry (which measures skinfold thickness), and the Body Mass Index (BMI). An obesity-defining body mass index (BMI) of 30 is accepted.

Research models of obesity are typically involved in associated conditions including cardiovascular disease, cancer, stroke, high blood pressure, high cholesterol, metabolic syndrome, non-insulin-dependent diabetes mellitus, cerebrovascular accidents, heart attacks, and other kinds of cardiovascular disease. Obesity exacts different impacts on the organism based on placement. Because adipocytes in the abdomen region have higher lipolytic activity than adipocytes in the lower extremities, the increased morbidity associated with abdominal adiposity is thought to be due to this difference.

The vascular/stromal compartment is home to macrophages and preadipocytes, and the lipid-storing adipocytes comprise fatty tissue. Adipose mass rises due to adipose cell hypertrophy caused by elevated lipid accumulation and subsequent hyperplasia. Also indicative of this upsurge are elevated levels of preadipocyte to adipocyte differentiation and many infiltrating macrophages. A steady blood flow to the fat cells allows them to differentiate and keep their bulk high. Such fatty tissue would be more vulnerable to ischemic damage, triggering apoptotic cascades in the wounded adipocytes and halting differentiation. Thus, adipocytes in white adipose tissue would suffer non-reversible ischemia damage, leading to a decrease in fatty mass, as would a peptidomimetic like Adipotide, research suggests.

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