Menotropin is a purified extract derived from the urine of postmenopausal women. Its key biological activity stems from containing significant concentrations of two essential gonadotropins:
●Follicle-Stimulating Hormone (FSH): Primarily stimulates the growth and maturation of ovarian follicles in women and Sertoli cells (crucial for spermatogenesis) in men.
●Luteinizing Hormone (LH): Triggers ovulation in women and stimulates Leydig cells in the testes to produce testosterone in men.
Unlike synthetic recombinant versions (like rFSH or r-hLH), HMG is a natural, biologically derived mixture of these hormones, along with trace amounts of other urinary proteins. Its fundamental medical purpose is to stimulate gonadal function – inducing ovulation in women with anovulatory infertility and stimulating spermatogenesis in men with hypogonadotropic hypogonadism.
