Exemestane is a steroidal aromatase inhibitor and a suicide inhibitor.https://www.giantrawsource.com/raw-steroid-powder/raws-powder-exemestane-aromasin.html
It permanently binds to the aromatase enzyme
Once bound, that specific aromatase enzyme is destroyed and cannot be reactivated
The body must produce new aromatase enzymes to restore estrogen production
This is different from non-steroidal AIs like anastrozole or letrozole, which bind reversibly and can detach from the enzyme.
Why This Matters
1. Longer-lasting estrogen suppression
Even after exemestane is stopped, estrogen levels may stay suppressed until new aromatase enzymes are made.
2. Less estrogen rebound
Because the enzyme is destroyed, exemestane is often associated with lower rebound estrogen compared to reversible AIs.
3. Different side-effect profile
Its steroidal structure may result in:
Slight androgenic activity
Potentially less negative impact on lipid profiles compared to non-steroidal AIs
