Binding to IGF-1 Receptors
IGF-DES binds to IGF-1 receptors on the surface of cells. These receptors are primarily found in muscle, bone, and other growth-related tissues. The binding activates intracellular signaling pathways that promote growth and repair.
Increased Protein Synthesis
By stimulating the Akt/mTOR pathway, IGF-DES enhances protein synthesis in muscle cells. This helps in muscle repair and growth after exercise or injury.
Improved Cell Differentiation and Proliferation
IGF-DES promotes the differentiation and proliferation of cells, particularly satellite cells in muscle tissue. These are essential for muscle regeneration and hypertrophy.
Localized Effects
IGF-DES has a shorter half-life than regular IGF-1, which limits its systemic effects but enhances localized action at the site of injection. This makes it particularly effective for promoting growth in specific muscles or tissues.
Reduced Binding to IGF-Binding Proteins
The structural modification of IGF-DES reduces its binding affinity to IGF-binding proteins (IGFBPs), which normally inhibit IGF-1 activity. As a result, IGF-DES remains more active and effective in promoting cellular growth and repair.
Applications
IGF-DES is primarily used for:
Accelerating muscle growth and repair.
Enhancing recovery after intense physical activity.
Promoting localized tissue growth.
Supporting overall cellular regeneration.
