How Does AICAR Work?

Mar 18, 2024 Leave a message

ATP Functions in the Cell

AICAR has demonstrated the following effects:

1) Activates The AMPK

In skeletal muscle, acute administration of AICAR reportedly activated the AMPK. Upon activation, AMPK stimulates energy-generating processes (i.e., glucose uptake and fatty acid oxidation) and shuts down the energy-consuming ones, thus making more energy available for use.

2) Increases Nitric Oxide Production

Nitric oxide helps blood vessels expand to promote proper blood flow. It can also provide various health benefits, such as better brain function, lower blood pressure, and improved exercise performance. Aside from that, it helps with penile erection.

3) Increases ATP Levels

In isolated human endothelial cells, AICAR treatment increased fatty acid and glucose oxidation, causing an increase in ATP production. Raised ATP levels reduce fatigue, increase strength and power, and improve body composition.

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4) Activates Glycogen Phosphorylase

AICAR activates glycogen phosphorylase and stimulates myocardial glycogenolysis in skeletal muscle cells. Both these processes help break down glycogen, a carbohydrate, into glucose. You could thus credit them for providing immediate energy.

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