The allure of Follistatin 344 is undeniable, but it is accompanied by immense and grave risks.
1.Purely Research-Based: It is sold for "research purposes only in a laboratory setting." It is not sterile, not approved for human use, and its safety profile is unknown. Injecting it is a massive gamble.
2.Tendon and Ligament Weakness: This is the most frequently cited and serious risk. Muscle tissue may grow rapidly, but the tendons, ligaments, and bones adapt at a much slower rate. This creates a severe strength-to-tissue-integrity mismatch, dramatically increasing the risk of catastrophic ruptures and injuries.
3.Organomegaly: The TGF-β pathway regulates the growth of all smooth muscle tissues, including the heart (myocardium). Uncontrolled inhibition of this pathway could theoretically lead to abnormal enlargement of the heart (cardiomegaly) and other internal organs, with potentially fatal consequences.
4.Autoimmune Reactions: Introducing a large foreign protein into the body carries the risk of triggering an immune response, where the body creates antibodies to attack the compound, leading to inflammatory reactions or rendering future doses ineffective.
5.Uncertain Long-Term Effects: The long-term consequences of profoundly altering such a fundamental biological pathway are completely unknown. It could have unforeseen carcinogenic or other pathological effects years down the line.
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