●Ghrelin Receptor Agonism: Binds strongly to the Growth Hormone Secretagogue Receptor (GHS-R1a), the same receptor activated by ghrelin. This is its primary mechanism.
●Pulsatile GH Release: Stimulates bursts of endogenous GH from the pituitary gland, typically resulting in 2-4 significant pulses per day when administered correctly, mirroring natural physiology more closely than constant HGH elevation.
●Synergistic Action: Works synergistically with the body's natural Growth Hormone Releasing Hormone (GHRH). Combining GHRP-6 with a GHRH (like CJC-1295 without DAC or Mod GRF 1-29) significantly amplifies the GH pulse magnitude and duration compared to either alone – a key strategy in peptide protocols.
●Stimulation of Ghrelin Pathways: Directly increases appetite (a well-known side effect) and influences gastric motility and potentially nutrient partitioning.
●Cortisol & Prolactin Modulation: Can transiently increase cortisol and prolactin levels, an important consideration for cycle management and side effect mitigation.
●Short Half-Life: Dictates frequent dosing (see below).
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