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Description
Aromasin was approved by the FDA in 1999, and it was first used in 2000. It is utilized in the treatment of both early and advanced breast cancer. This drug is an aromatase inhibitor. Aromasin is also known by the brand names Exemestane, Arimidex, and others.
Male bodybuilders who want to avoid the negative consequences of high estrogen levels, such as gynecomastia and water retention, frequently use it. If you have a history of breast cancer or benign breast disease, you should avoid using this medication since, unless prescribed by your doctor, it will not prevent breast cancer or benign breast disease. This is due to the fact that it is more commonly used to treat estrogen-related diseases than to prevent estrogen-related conditions. Some evidence indicates that it may help patients avoid kidney stones, but further research is needed.
Aromasin is a substance that is taken orally and is normally dosed at 25mg per pill. This dose is commonly administered to middle-aged males. The serum level of aromasin normally decreases with continuous use, enhancing the likelihood of undesirable consequences such as decreased libido or erectile dysfunction. This dosage is not always suitable for women.

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How Does Aromasin Work?
Aromasin (Exemestane) is binding to aromatase enzymes and disables them. Unlike the other two AIs, Aromasin is a suicidal aromatase inhibitor. This means that as soon as it binds to the aromatase enzymes, it permanently disables them. This reduces the risk of estrogen rebound (sudden spike) when stopping the use of AI. That's why Aromasin is considered a superior AI over the other two. Femara (Letrozole) and Arimidex (Anastrozole).
Aromatase enzymes are responsible for converting testosterone (and other similar hormones) into estrogen (and other similar hormones).
Why Do Bodybuilders Use Aromasin?
In medical settings, doctors usually prescribe Aromasin to women suffering from breast cancer caused by estrogen. That's why Aromasin (Exemestane) is also an anti-cancer drug. Lowering estrogen helps reduce breast cancer.
However, bodybuilders also use Aromasin to lower estrogen when this hormone gets too high. It occurs when bodybuilders and athletes use steroids that aromatase into estrogen. Not all steroids aromatase, but testosterone does. Considering that you need testosterone in all steroid cycles, it is important to have at least some form of estrogen protection (like Aromasin) handy.
When you use testosterone (and/or other aromatizing AKA "wet" steroids), there's an abundance of testosterone that converts into estrogen, which leads to too high estrogen levels. As a result of abnormally high levels of estrogen, bodybuilders have side effects. Some popular high estrogen side effects are gynecomastia (male breast enlargement), water retention (excess fluid), and erectile dysfunction (can't get and/or maintain an erection) among others. These are popular side effects of anabolic steroids.
So, Aromasin (or other AIs) are commonly used during the cycles of steroids in order to deal with these issues. So, bodybuilders and other anabolic steroid users run them as ancillaries to prevent and/or control and/or fight off the side effects of steroids. Those related to too high estrogen.
Exemestane Mechanism Of Action
The development of breast cancer cells may be estrogen-dependent. Aromatase (exemestane) is the primary enzyme responsible for converting androgens to estrogens in both pre- and postmenopausal women. While the ovary is the primary source of estrogen (mainly estradiol) in premenopausal women, the aromatase enzyme in peripheral tissues converts adrenal and ovarian androgens (androstenedione and testosterone) to estrogens (estrone and estradiol) in postmenopausal women. For some postmenopausal women with hormone-dependent breast cancer, estrogen deprivation with aromatase inhibition is an effective and selective treatment.
Exemestane is a steroidal aromatase inactivator that is structurally similar to the natural substrate androstenedione. It binds to the active site permanently, producing permanent inhibition and required de novo synthesis to restore enzymatic function. Exemestane considerably decreases circulating estrogen concentrations in postmenopausal women but has no effect on corticosteroid or aldosterone production in the adrenal gland. This decrease in serum and tumor estrogen concentrations slows tumor development and disease progression. Exemestane has no effect on other enzymes involved in the steroidogenic pathway until it reaches a concentration 600 times that of the aromatase enzyme.
Aromasin Side Effects – What To Consider?
Now, to get a clear picture – you use steroids and they convert into estrogen. It leads to high levels of estrogen and side effects related to too high levels of this hormone. Now you introduce Aromasin (Exemestane) or at least other AIs to your cycle to control them by reducing the levels of estrogen.
However, it's important to understand that it comes with its own side effects.
I have to mention that most bodybuilders tolerate Aromasin very well. That's because:
Males need lower doses than women dealing with hormonally positive breast cancer
Males need much lower estrogen levels than women
Bodybuilders don't need to use anti-estrogens for so long periods as women do
So, assuming that you do not have some pre existing health issues that could prevent you from using Aromasin (usually because it may worsen them), that you don't have any abnormal reaction to it (such as allergies or hyper reaction or something in this matter) – you wouldn't experience side effects. Of course, as long as you use it correctly. That's why most bodybuilders don't experience side effects.
How Much Aromasin Should I Take On Cycle
GP Exemestane is often taken on the first day of the cycle. Because too much estrogen suppression can lead to decreased muscle growth and sexual drive, it's vital to maintain GP Exemestane levels in check. One 25 mg pill taken once a day should be enough to adequately enhance natural testosterone levels during PCT or prevent estrogen-related negative effects. This allows only a trace quantity of estrogen to be present in the body. This dosage is also sufficient to ensure that estrogen levels do not fall below the dangerous threshold.
While estradiol is only one of several estrogenic hormones, it is frequently referred to as the most important "master hormone" in women's health due to its direct influence on virtually every other hormone in the body. The smallest amount of estradiol should be present to maintain a woman's natural hormonal balance. Estradiol levels are often determined using a urine home test, a serum blood test, or a saliva test.
Expected Results From Aromasin Use
Aromasin users can anticipate to observe a significant decrease in estrogen levels in their bodies. This is due to the aromatase enzyme being inhibited. This is the enzyme in the body that converts testosterone to estrogen. Aromasin and Testosterone: Aromasin inhibits the aromatase enzyme, which converts testosterone into estrogen.
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