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Description
The main mechanism of action of Cialis involves the inhibition of the PDE5 enzyme. In the presence of sexual stimulation, the release of nitric oxide in the erectile tissue of the penis leads to the activation of an enzyme called guanylate cyclase. Guanylate cyclase increases the levels of cyclic guanosine monophosphate (cGMP), which relaxes the smooth muscles in the penile blood vessels, allowing increased blood flow into the penis. This increased blood flow results in an erection.
PDE5 is an enzyme that breaks down cGMP, reducing the amount available for maintaining an erection. By inhibiting PDE5, Cialis prolongs the effects of cGMP, making it easier for men with ED to achieve and maintain an erection during sexual activity.
Cialis relaxes muscles of the blood vessels and increases blood flow to particular areas of the body.
Cialis is used to treat erectile dysfunction (impotence) and symptoms of benign prostatic hypertrophy (enlarged prostate).
Another brand of tadalafil is Adcirca, which is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women. Do not take Cialis while also taking Adcirca, unless your doctor tells you to.
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