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Description

Tadalafil (Cialis) is used to treat erectile dysfunction (ED, impotence; inability to get or keep an erection), and the symptoms of benign prostatic hyperplasia (BPH; an enlarged prostate) which include difficulty urinating (hesitation, dribbling, weak stream, and incomplete bladder emptying), painful urination, and urinary frequency and urgency in adult men. Tadalafil (Adcirca) is used to improve the ability to exercise in people with pulmonary arterial hypertension (PAH; high blood pressure in the vessels carrying blood to the lungs, causing shortness of breath, dizziness, and tiredness). Tadalafil is in a class of medications called phosphodiesterase (PDE) inhibitors. It works to treat erectile dysfunction by increasing blood flow to the penis during sexual stimulation. This increased blood flow can cause an erection. Tadalafil treats PAH by relaxing the blood vessels in the lungs to allow blood to flow more easily.

If you are taking tadalafil to treat erectile dysfunction, you should know that it does not cure erectile dysfunction or increase sexual desire. Tadalafil does not prevent pregnancy or the spread of sexually transmitted diseases such as human immunodeficiency virus (HIV).

How does Cialis work?

Cialis (Tadalafil) works by relaxing the blood vessels, specifically in the smooth muscle tissue of the blood vessels within the body. This process improves blood flow to certain areas, notably the penis, to facilitate and maintain an erection when there is sexual stimulation. Here's a closer look at the mechanism:

PDE5 Inhibition:

Cialis blocks an enzyme called phosphodiesterase type 5 (PDE5), which is responsible for breaking down cGMP, a molecule that helps control blood flow.

Increased cGMP Levels:

By inhibiting PDE5, Cialis allows for increased levels of cGMP, which relaxes smooth muscle tissue and widens blood vessels in the penis, leading to improved blood flow and a stronger, sustained erection.

Response to Sexual Stimulation:

It's important to note that Cialis doesn't cause an automatic erection; it only works in response to sexual arousal. When stimulation occurs, the increase in cGMP levels supports the physiological process of erection.

Long Duration:

Cialis has a longer half-life than other similar medications, meaning it remains active in the body for up to 36 hours. This duration allows for greater flexibility in timing for those who take it.

In addition to treating erectile dysfunction, Cialis is also used to relieve symptoms of benign prostatic hyperplasia (BPH), such as difficulty in urination, by relaxing the muscles in the bladder and prostate.

How fast does Cialis work?

Cialis (Tadalafil) typically starts working within 30 minutes to 2 hours after taking it, with effects lasting up to 36 hours in the body. This longer duration is why Cialis is often referred to as the "weekend pill." Here's a breakdown of its timing and what influences it:

Onset Time:

Most people feel the effects within 30 to 60 minutes.

For some, it might take closer to 2 hours, depending on factors like individual metabolism and whether it was taken on a full stomach.

Duration:

Cialis stays active in the body for up to 36 hours, which is longer than other similar medications like Viagra, allowing more spontaneity.

Factors Affecting Speed and Effectiveness:

Food Intake: Unlike some medications, Cialis is less affected by food, so it can be taken with or without a meal.

Dosage: Higher doses (10-20 mg) tend to act faster than lower doses (5 mg daily dose).

Health Factors: Individual health, age, and liver or kidney function can affect how quickly it works.

For best results, take Cialis at least 30 minutes to an hour before sexual activity and consider its long-lasting effect if taken in advance.

How should this medicine be used?

Tadalafil comes as a tablet to take by mouth. It may be taken with or without food.

If you are taking tadalafil to treat erectile dysfunction, follow your doctor's directions and the guidelines in this paragraph. There are two different ways to take tadalafil, either daily or on an as needed basis. Talk to your doctor about which dosing schedule is right for you. Tadalafil is sometimes taken as needed, usually at least 30 minutes before sexual activity and not more often than once every 24 hours. Your doctor will help you decide the best time for you to take tadalafil before sexual activity. Tadalafil is also sometimes taken once a day every day without regard to timing of sexual activity. You may attempt sexual activity at any time between doses. If you are taking tadalafil on a regular schedule, take it at around the same time every day. If you have certain health conditions or are taking certain medications, your doctor may tell you to take tadalafil less often or may prescribe a lower dose to be taken once a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take tadalafil exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

If you are taking tadalafil to treat PAH or BPH, follow your doctor's directions and the guidelines in this paragraph. You should take tadalafil one time a day. Take all of the tablets for your daily dose at one time each day; do not divide the tablets to take as separate doses. Take tadalafil at around the same time every day. If you are already taking medication to treat BPH, your doctor may tell you to stop taking your other medication at least one day before starting treatment with tadalafil. Follow your doctor's directions carefully, and ask your doctor or pharmacist to explain any part you do not understand.

If you are taking tadalafil for erectile dysfunction, your doctor will probably start you on an average dose of tadalafil and increase or decrease your dose depending on your response to the medication. Tell your doctor if tadalafil is not working well or if you are experiencing side effects.

If you are taking tadalafil for PAH, you should know that tadalafil controls PAH but does not cure it. Continue to take tadalafil even if you feel well. Do not stop taking tadalafil without talking to your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

What special precautions should I follow?

Before taking tadalafil,

tell your doctor and pharmacist if you are allergic to tadalafil, any other medications, or any of the ingredients in tadalafil tablets. Ask your pharmacist for a list of the ingredients.

tell your doctor if you are taking or have recently taken riociguat (Adempas) or nitrates such as isosorbide dinitrate (Isordil), isosorbide mononitrate (Monoket), and nitroglycerin (Minitran, Nitro-Dur, Nitromist, Nitrostat, others). Nitrates come as tablets, sublingual (under the tongue) tablets, sprays, patches, pastes, and ointments. Ask your doctor if you are not sure whether any of your medications contain nitrates. Your doctor will probably tell you not to take tadalafil if you are taking nitrates.

tell your doctor if you are taking street drugs containing nitrates ('poppers') such as amyl nitrate, butyl nitrate, or nitrite while taking tadalafil. Your doctor will probably tell you not to take tadalafil if you are taking street drugs containing nitrates.

you should know that tadalafil is available under the brand names Adcirca and Cialis. You should only be treated with one of these products at a time.

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