Description
Drostanolone propionate, or dromostanolone propionate, sold under the brand names Drolban, Masteril, and Masteron among others, is an androgen and anabolic steroid (AAS) medication which was used to treat breast cancer in women but is now no longer marketed. It is given by injection into muscle.
Side effects of drostanolone propionate include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire. It has no risk of liver damage. The drug is a synthetic androgen and anabolic steroid and hence is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT).It has moderate anabolic effects and weak androgenic effects, which give it a mild side effect profile and make it especially suitable for use in women. The drug has no estrogenic effects.Drostanolone propionate is an androgen ester and a long-lasting prodrug of drostanolone in the body.
Drostanolone propionate was first described in 1959 and was introduced for medical use in 1961.In addition to its medical use, drostanolone propionate is used to improve physique and performance.The drug is a controlled substance in many countries and so non-medical use is generally illicit.
Drostanolone propionate, also known as Masteron Propionate, is an anabolic androgenic steroid derived from dihydrotestosterone (DHT). It is a short-ester version of drostanolone, meaning it has a faster release time and a shorter half-life compared to the enanthate ester.
Drostanolone propionate is primarily used in bodybuilding and athletic circles for its ability to promote muscle definition, hardness, and a dry appearance. It is commonly utilized during cutting phases or pre-competition to enhance muscular aesthetics. Due to its anti-estrogenic properties, it is often favored for reducing water retention and minimizing the risk of estrogen-related side effects.
Pharmacokinetics
Drostanolone propionate is a prodrug of drostanolone. Like other AAS, drostanolone is an agonist of the androgen receptor (AR). It is not a substrate for 5α-reductase and is a poor substrate for 3α-hydroxysteroid dehydrogenase (3α-HSD), and therefore shows a high ratio of anabolic to androgenic activity. As a DHT derivative, drostanolone is not a substrate for aromatase and hence cannot be aromatized into estrogenic metabolites. While no data are available on the progestogenic activity of drostanolone, it is thought to have low or no such activity similarly to other DHT derivatives. Since the drug is not 17α-alkylated, it is not known to cause hepatotoxicity.
Drostanolone propionate, via its active form drostanolone, interacts with the AR and activates a cascade of genetic changes, including increased protein synthesis (anabolism) and decreased amino acid degradation (catabolism). It also induces a reduction or inhibition of prolactin or estrogen receptors in the breasts, which is linked to its antitumor effects.
Drostanolone propionate is not active via the oral route and must be administered via intramuscular injection.The elimination half-life of the drug via this route is approximately 2 days. It has a much longer elimination half-life via intramuscular injection than drostanolone. Drostanolone propionate is metabolized into drostanolone, which is the active form.
Chemistry
See also: List of androgens/anabolic steroids and List of androgen esters
Drostanolone propionate, or drostanolone 17β-propionate, is a synthetic androstane steroid and a derivative of DHT.It is the C17β propionate (propanoate) ester of drostanolone, which itself is 2α-methyl-4,5α-dihydrotestosterone (2α-methyl-DHT) or 2α-methyl-5α-androstan-17β-ol-3-one.
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