High Purity Sarms YK11

Description

YK-11 may be the most powerful muscle building compound on the entire planet, perhaps this is a arrogant claim, but I will deeply support it, YK-11 is the strongest SARM for building muscle mass. While other SARMs work by targeting androgen receptors (ARs) in the body, YK-11 is actually an anti-myostatin inhibitor.that has gained attention in the fitness and bodybuilding community. It is known for its potential anabolic properties, which means it may help in promoting muscle growth and strength.

YK11Benefits For Bodybuilding

Truthfully, a lot of the above health benefits could easily be applied to bodybuilders.

From stimulating increased lean muscle mass, to boosting fat loss and protecting your bones from density loss and fractures; by taking just 5mg of YK-11 a day (over 4 weeks) you can: gain over 5lbs of lean muscle; increase your chest, arm and calf measurements, and lose 2% body fat.

PLEASE NOTE: this figure is based on the average results of a lot of users.

What makes YK 11 SARM so appealing to bodybuilders is the way that it builds muscles by facilitating follistatin.

By tackling muscle growth in such a unique way; you can escape with little to no side effects and will suffer from only mild testosterone suppression – which can be prevented with good old PCT.

In fact, users state that you will begin seeing muscle mass gains in as little as a week. Plus, it has proven to be beneficial in both bulking and cutting cycles.

Think about it…

This super SARM can technically help you to pile on lean muscle fast (during bulking), whilst helping you to burn fat and harden muscles during a calorie deficit (cutting).

Who can say no to claims like that? It is no wonder it is so popular.

But here is the thing…

It may be able to do all of this (in theory), but there is a massive difference between what happens at a cellular level and what will actually occur in your body. Without human trials/studies to substantiate these bold claims, all they really are, are words. Nothing more.

Hell, even YK11 reviews are not 100% reliable, as these claims are clouded by their varying dosages, Y11 cycles and what they stacked it with.

DISCUSSION

YK11 is a novel steroidal compound that we synthesized previously.²⁴⁾ We demonstrated that YK11 act as a partial agonist of AR in a reporter gene assay.²⁴⁾ However, YK11 shows interesting gene selective transcriptional activation of endogenous target genes. In human AR-positive MDA-MB 453 breast cancer cells, YK11 treatment induced FKBP51 mRNA expression similar to DHT treatment, though YK11 did not induce SARG mRNA expression, which DHT treatment can do.²⁴⁾ Further, we showed that YK11 induced myogenic differentiation similar to DHT. Selective induction of follistatin mRNA was found to be the unique mechanism for YK11 activity, because the induction was not shown by DHT.²⁵⁾ Thus, YK11 is a remarkable novel type of SARM. In this study, we assessed the effect of YK11 on osteogenic activity using MC3T3-E1 cells.

Osteoblast cell proliferation is the first step of bone formation.^27,28) In Fig. 1, we showed that YK11 accelerates osteoblast cell proliferation similar to DHT. A previous report has shown that androgens induce Akt-phosphorylation through AR, resulting in osteoblast cell proliferation.^29,30) In Fig. 4, we demonstrated that YK11 rapidly increases phosphorylated Akt protein in a 15-min treatment, which suggests that YK11 activates the non-genomic action of AR similar to DHT. Thus, these observations suggest that YK11 accelerates osteoblast cell proliferation by AR-mediated non-genomic activity. AR directly interacts with the p85α regulatory subunit of PI3K in the cytosol.^29,30) Interaction between p85α and AR promotes PI3K activation and generation of phosphatidylinositol (3,4,5)-trisphosphate (PIP3) to induce Akt phosphorylation. This interaction was induced by treatment with the AR agonist R1881. Direct interaction is mediated by binding of the N-terminal domain of AR to the SH2 domain of the p85 regulatory subunit. Previously, we showed that YK11 could not induce the NH₂- and carboxyl-terminal (N/C) interaction of AR in contrast to DHT. Non-genomic action of AR may not require N/C interaction as YK11 could induce Akt phosphorylation similar to DHT. This observation is important for determining the action of SARMs and further investigation is required.

OPG is an early differentiation marker that is one of the most frequently used markers to demonstrate osteoblast differentiation. OPG is reported to belong to the tumor necrosis factor (TNF) receptor superfamily as a soluble factor that inhibits osteoclast differentiation.³¹⁾ OPG is a soluble decoy receptor for receptor activator of nuclear factor kappa-B ligand, which activates osteoclasts.^31,32) OC expression in osteoblast is used as a valid marker of osteoblast differentiation and mineral deposition because OC is expressed in osteoblasts at the matrix mineralization phase. In Fig. 3, induction of these osteoblast differentiation markers was observed in YK11-treated cells.

In conclusion, we demonstrated that YK11 promoted osteoblast proliferation and differentiation, and increased ALP activity (a marker of osteoblastic maturation) and calcium deposits as stained with alizarin red S (a marker of mineralization) in Fig. 2. Similar to DHT, this activity may be mediated by the non-genomic action of AR. Thus, YK11 is useful as a potential anabolic SARM for androgen deficiency related diseases in men, such as osteoporosis. It is known that the selectivity of SARMs is different of each.³³⁾ Thus, to investigate for activity of each SARMs is essential. Since YK11 shows unique myogenic differentiation mechanism in C2C12 cells different from DHT²⁵⁾ and reported SARMs (unpublished observation), YK11 is a novel type of SARMs. This is the first report for the effect of YK11 on different tissue. However, this compound needs to be subjected to further investigations, such as in vivo experiments.

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