SR9011 High Quality CAS: 1379686-29-9

Description

SR 9011 is a synthetic compound known as a Selective Androgen Receptor Modulator (SARM), which specifically targets the Rev-ErbA receptor. Developed by the Scripps Research Institute, SR 9011 is often researched for its potential applications in enhancing physical performance and metabolic activity. By binding to the Rev-ErbA receptor, SR 9011 can influence various physiological processes, including circadian rhythm, lipid and glucose metabolism, and the regulation of mitochondrial function. This makes it a subject of interest for scientists looking to address conditions such as obesity, diabetes, and cardiovascular diseases.

One of the notable effects of SR 9011 is its ability to increase exercise capacity. Studies in animal models have demonstrated that administration of SR 9011 can significantly enhance endurance and physical performance. This is largely due to the compound's impact on skeletal muscle mitochondria, leading to an increase in energy expenditure and a reduction in stored fat. These properties suggest potential uses for SR 9011 not only in sports and fitness but also in medical scenarios where improving metabolic health and physical capacity is beneficial.

Clinical Data

Is Sr9011 A SARM?

A SARM is a Selective Androgen Receptor Modulator. That means that it selectively activates androgen receptors. This mostly means being a selective agonist of androgen receptors in bone and muscle tissue only.

Some SARMs are agonists of those androgen receptors, but can also be less targeted. S-23 and RAD-140 are the main SARMs that are very potent and closer to steroids because they less easily target muscle and bone tissue receptors. But here's the thing. SR9011 isn't a SARM at all. Its mechanism of action and its effects are completely different.

That's the same with Sr 9009 and Cardarine. Both of which need to also be discussed within this review so you understand how they all subtly vary yet also achieve the same results.

How SR9011 Works

Once processed by the liver, SR9011 works in the same way as Sr9009, by increasing the constitutive repression of genes regulated by Rev-ErbA and Rev-ErbAB (Beta).

A repressor is a DNA binding protein (in the case of Sr9011 an artificial one) that inhibits gene expression.

In inhibiting the expression of genes regulated by Rev-Erba and Rev-ErbAB (Beta), it produces results described as "hormone and metabolic modulation").

In studies, Activation of Rev-Erba in mice increased exercise capacity by increasing mitochondria counts in skeletal muscle. This is the same mechanism of action in both SR-9009 and SR-9011.

So what this is doing is basically affecting gene expression in a dose-dependent manner. In doing this it affects fatty acid processing, glucose production and availability, metabolism, and fat cell growth.

It even has a strong effect on the circadian rhythm (the natural desire to sleep and wake). This effect promotes better sleep and rest and increased wakefulness.

Before I talk specifically about bodybuilding benefits, I want to just mention the circadian rhythm thing. Sr9011 was observed in my studies to completely suppress the circadian pattern of expression in continually dark circumstances.

So, although this can promote wakefulness, and alertness, and make you feel incredibly rested, too much of it close to sleep can mean your body clock is messed up and you'll end up struggling to sleep.

SR9011 Dosage & Cycle Length

You could use this indefinitely. It's not anabolic, and in no studies on mice were any side effects noted. However, it's never been through human trials. This applies to both SR-9011 and its close variant SR-9009. So I would be wary of using it that way.

Therefore, I always keep a cycle length of 12 weeks or less. Then I give my body at least a two-month break. That allows it to reset and for me to see if there are any problems.

In terms of SR9011 dosage, you're in the same ballpark as with Sr9009.

10 mg is a low dose, 20 mg typical dose, and 30 mg is a high dose. Although effects are dose-dependent, doses above 50 mg in humans (anecdotal bodybuilding community evidence I've been researching, along with my own experiences) suggest that it starts to plateau between 30 mg and 50 mg.

So for me, my recommendation if you are using it on its own or in a stack is 10 mg to see how it goes. Kick it up to 15 mg or 20 mg after that, don't go above 30 mg.

I'd also dose it in the morning as a single dose. Although some people split up, you are running the danger of more strongly altering your circadian rhythm through the night. This can lead to problems down the line with altered sleep patterns.

How To Stack SR 9011

The power of SARMs is in the stack. On their own they are potent, but you have to work really hard to derive the full benefits. Although that's the same with SARMs stacks, because you are taking multiple SARMs that are hitting things in different ways, you multiply your rewards for the real effort you put in.

SR-9011 is no different. It can be used on its own to increase energy output, muscle recovery and repair, and wakefulness.

But because of those properties, it can underpin any SARMs stack. Bulking, cutting, or maintenance. It can be even used post cycle, or continued post cycle (although I wouldn't always advise it).

This is an example of what I mean. Here's a classic bulking stack that I personally use:

10 mg RAD-140

15 mg MK-677

10 mg SR-9011 (or Sr9009 or Cardarine)

PCT supplement required

Maximum 12 week cycle

By underpinning it with this energy booster and recovery drug, you'll maximize your gains, while shredding fat, and building strength.

SR-9011 Vs SR-9009: Which Is Best?

I think you've already worked out there is not a huge amount of difference between SR-9011 and SR-9009. However, when it comes to a close comparison of SR-9011 Vs SR-9009, there is a slight difference in balance.

SR-9009 appears to be an agonist of REVERB-a only, while SR-9011 is both an A and B agonist.

That difference means that SR-9011 will affect the circadian rhythm balance more, while SR-9009 is slightly more focused on the fatty acid and glucose metabolism side.

In real terms, you'll get slightly more energy from one, and slightly more benefit from wakefulness and recovery from the other. But in practical terms, it's minimal.

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