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| Other Name: | Femara | MF: | C17H11N5 |
|---|---|---|---|
| MW: | 285.3 | MP: | 181-183°C |
| Storage Temp: | -20°C Freezer | Appearance: | White Crystalline Powder |
| High Light: | anti estrogen products,anti estrogen drugs | ||
99.2% Safe & Effective Anti-Estrogen Letrozole / Femara Powder Pharmaceutical Grade
Description:
Letrozole is a medication that belongs to a class of drugs called aromatase inhibitors. It is primarily used in the treatment of hormone receptor-positive breast cancer in postmenopausal women. Letrozole works by inhibiting the enzyme aromatase, which is responsible for the conversion of androgens (male hormones) into estrogen (female hormone). By blocking this conversion, letrozole reduces the levels of estrogen in the body, which can help slow down or stop the growth of estrogen-dependent breast cancer cells.
Here are some key points about letrozole:
Breast cancer treatment: Letrozole is commonly used as an adjuvant therapy or as a first-line treatment for hormone receptor-positive breast cancer in postmenopausal women. It may also be used in cases where breast cancer has recurred or spread to other parts of the body.
Hormone-dependent cancers: Letrozole is effective in treating hormone receptor-positive breast cancers, which means the cancer cells have receptors that are stimulated by estrogen. By reducing estrogen levels, letrozole helps to inhibit the growth of these cancer cells.
Administration: Letrozole is taken orally in the form of tablets. The recommended dosage and duration of treatment will depend on the specific circumstances and should be determined by a healthcare professional.
Side effects: Like any medication, letrozole can cause side effects. Common side effects may include hot flashes, joint or muscle pain, fatigue, headache, dizziness, and gastrointestinal disturbances. It may also have an impact on bone health, so regular monitoring and appropriate supplementation may be required.
Hormonal changes: Letrozole significantly reduces estrogen levels in the body, which can lead to menopausal symptoms such as vaginal dryness, mood changes, and decreased libido.
Dosage:
The dosage of letrozole prescribed can vary depending on the specific condition being treated, the individual's response to the medication, and other factors. It's important to follow the specific instructions provided by a healthcare professional. The following are general guidelines for letrozole dosages in the treatment of breast cancer:
The standard dosage for letrozole in the treatment of early or advanced breast cancer is 2.5 mg taken orally once daily. This is the typical starting dose.
Letrozole is usually taken continuously, meaning it is taken every day without any breaks, unless otherwise instructed by a healthcare professional.
The duration of treatment can vary depending on the specific circumstances and will be determined by a healthcare professional. In some cases, letrozole may be prescribed for several years as an adjuvant therapy to prevent cancer recurrence.
Letrozole is typically used in postmenopausal women. If a premenopausal woman is prescribed letrozole, it may be combined with ovarian suppression therapy to achieve menopause-like hormone levels.
Dosage adjustments may be necessary based on individual factors such as side effects, response to treatment, and overall health. It's important to communicate any concerns or changes in health to a healthcare professional.
It's crucial to consult a healthcare professional for personalized advice and recommendations regarding the specific dosage of letrozole based on individual circumstances. They will consider factors such as the stage and type of breast cancer, other medications being taken, and overall health to determine the appropriate dosage and duration of treatment.
What is letrozole used for in fertility?
Letrozole is sometimes used off-label in fertility treatments, particularly in women who are experiencing ovulation problems or infertility due to anovulation (lack of ovulation) or irregular ovulation. In such cases, letrozole is used as an ovulation induction medication.
Here's how letrozole is used in fertility treatment:
Ovulation induction: Letrozole helps stimulate the development and release of eggs from the ovaries by inhibiting the production of estrogen. By reducing estrogen levels, it can lead to increased production of follicle-stimulating hormone (FSH), which promotes the growth and maturation of ovarian follicles containing eggs.
Polycystic ovary syndrome (PCOS): Women with PCOS often have irregular ovulation or anovulation. Letrozole can be used to induce ovulation in these cases. It may be preferred over other ovulation induction medications, such as clomiphene citrate, due to its potential to result in a higher rate of ovulation and pregnancy.
Timing and monitoring: Letrozole is typically taken orally for several days early in the menstrual cycle. The dosage and duration will be determined by a healthcare professional based on the individual's specific situation. Ovulation is then monitored through ultrasound scans and hormone level measurements to determine the optimal timing for sexual intercourse or assisted reproductive techniques like intrauterine insemination (IUI).
It's important to note that using letrozole for fertility treatment is considered an off-label use since it is not specifically approved for this purpose. However, many healthcare professionals may prescribe letrozole off-label based on clinical experience and studies showing its effectiveness in inducing ovulation.
As with any medication, letrozole may have potential side effects, and its use in fertility treatment should be monitored by a healthcare professional. Common side effects may include hot flashes, headaches, nausea, and fatigue. Multiple pregnancies (such as twins or more) can also occur, so close monitoring is essential.
If you are considering letrozole for fertility treatment, it's important to consult a healthcare professional who specializes in reproductive medicine. They will be able to evaluate your specific situation, discuss the potential benefits and risks of letrozole, and provide appropriate guidance and monitoring throughout the treatment process.
Lab Test Result:
| Test Items | Specification | Results |
| Appearance | White or off-white crystaline powder | White crystalline powder |
Solubility | Soluble in Chloroform; Soluble in ethanol when heated |
Conform |
ldentification | Maximum absorption in wavelength of 240nm Minimum absorption in wavelength of 215nm | Conform Conform |
| Infrared spectrum should be in accordance the dominant peak of contrast | In accordance with the dominant peak of contrast | |
| Melting points | 181℃-183℃ | 182℃ |
| Related substances | ≤0.5% | 0.3% |
| Single impurity | ≤0.3% | 0.2% |
| Loss on drying | ≤1.0% | 0.8% |
| Assay | ≥98.0% | 99.2% |
| Conclusion | It conforms with Enterprise Standard | |

Anti-Estrogen Series | |
Tamoxifen Citrate (Nolvadex) |
Dutasteride (Avodart) |
Clomifene Citrate (Clomid) |
Finasteride (Proscar) |
Letrozole (Femara) |
Formestane (Lentaron) |
Toremifene Citrate (Fareston) |
Cabergoline (Caber) |
Exemestane (Aromasin) |
Raloxifene Hydrochloride |
Anastrozole (Arimidex) |
Pramipexole |
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