Powder Dutasteride

Description

"Dutasteride is a medication that blocks an enzyme known as 5-alpha reductase (5-AR)," explains Dr. Simon Pimstone, founder, and director, at XYON Health Inc. "This enzyme is responsible for the production of dihydrotestosterone (or DHT), which is the androgen hormone that plays a key role in prostate development and male pattern hair loss."

Dutasteride is often used in situations where hair loss is extensive or not responsive to another treatment known as finasteride.

Both of these treatments block 5-AR, however, Pimstone points out that dutasteride inhibits two forms of the enzyme known as isoforms I and II, whereas finasteride only acts on isoform II.

Finasteride also only blocks about 70% of the conversion of testosterone into DHT. Dutasteride can block more than 90%Trusted Source.

Taking dutasteride orally works by stopping the conversion of testosterone to DHT in the body so that the DHT doesn't have the chance to reach the hair follicles.

When applied topically, it works by stopping DHT conversion in the hair follicles.

Pharmacological action

Testosterone is converted into dihydrotestosterone under the action of 5α-reductase, and dihydrotestosterone can promote the growth and development of the prostate. 5α-reductase has two subtypes, namely type I isoenzyme and type II isoenzyme. Type I isoenzyme has reproductive activity, and type II isoenzyme participates in the conversion of testosterone in the skin and liver. This product is a relatively specific 5α-reductase inhibitor. It inhibits type I and type II 5α-reductase isoenzymes by forming an enzyme complex, inhibits the conversion of testosterone into dihydrotestosterone (DHT), and then inhibits the production of androgen dihydrotestosterone, thereby inhibiting the growth of the prostate in patients with benign prostatic hyperplasia (BPH). 0.5 mg per day, after 1 to 2 weeks of medication, the effect of this product on reducing DHT reaches a peak, and plasma DHT can be reduced by 85% to 90%. Patients with enlarged prostates take 5 mg per day, and DHT is significantly reduced in 12 weeks.

Pharmacokinetics

This drug is rapidly absorbed orally, with a bioavailability of about 60%. After oral administration of 0.5 mg, the blood drug concentration reaches the peak value in 2 to 3 hours. When taken with food, the peak concentration (Cmax) decreases by 10% to 15%. The drug has a distribution volume of 300 to 500 L, a plasma protein binding rate of up to 99%, and an α1-acid glycoprotein binding rate of 96.6%. The drug concentration in the semen of healthy volunteers is 3.4 ng/ml, which is similar to that in plasma. The plasma drug concentration reaches steady state after continuous use of this drug for 6 months. This drug is extensively metabolized by hepatic cytochrome CYP3A4 and is mainly excreted in the feces, of which 5% is unmetabolized drug, 40% is metabolites, and less than 1% is unmetabolized drug in urine. The elimination half-life of this drug is about 5 weeks [2].

How effective is dutasteride for hair loss?

So, just how effective is dutasteride when used as an off-label treatment for hair loss?

When compared to finasteride, Pimstone says dutasteride is a far more active inhibitor of the 5-AR enzyme and hence has a more potent effect in lowering DHT levels.

In particular, he says when used topically, dutasteride can have a strong clinical effect as it delivers a higher amount of the medication to the target hair follicle.

"A number of well-controlled and observational clinical studies have now shown clear clinical benefit of dutasteride over finasteride," Pimstone surmises. "The clinical benefit of dutasteride appears as a result of its potent effect on the 5-AR enzyme and DHT."

In one meta-analysisTrusted Source conducted in 2019, dutasteride showed a significant increase in the total hair count compared with finasteride.

Meanwhile, the results of an older randomized placebo-controlled studyTrusted Source of dutasteride versus finasteride, found that the former was more effective in increasing target area hair count.

While there is some research supporting the effectiveness of dutasteride for hair loss, it may be best to manage your expectations.

Using dutasteride can be an effective tool for stopping hair loss, but experts say to keep in mind that it isn't going to grow hair.

However, there are combinations of finasteride and minoxidil that have been shown to be effective treatments to stop hair loss and promote hair growth at the same time.

What are the potential risks of using dutasteride to treat hair loss?

As with all medications, particularly off-label treatments, there are risks and side effects to consider.

It's also important to note that dutasteride is not FDA-approved as a hair loss treatment so you'll need to exercise extra caution if using it for this purpose.

Some potential side effects include skin and scalp irritation, cold sweats, and dizziness.

"In some cases, you might experience depression, chest pains, swelling, sexual dysfunction, and suicidal thoughts," says Abdullah.

Generally though, Pimstone believes that topical formulations - provided the ingredients are used at concentrations where they are known to be safe - should be safe to use, "as these topical forms generally deliver less dutasteride into the systemic circulation than oral forms."

He also notes that oral and topical dutasteride for male pattern hair loss has been studied clinically for years.

"With this extensive clinical experience, we are not aware of any serious adverse reactions that have highlighted significant risks with oral formulations," he concludes.

Other effective ways to prevent and treat hair loss

How safe is Dutasteride (Avodart)?

1. Dutasteride is more likely to cause a decrease in sperm count, and this will last for a considerable period of time. Even after stopping the drug, the decrease in sperm count will continue for a long time. Does Dutasteride cause infertility? There is no conclusion in the US FDA report. In terms of reduced sexual ability, the incidence is higher than that of 1 mg of Finasteride.
2. In addition, because there are many type 1 5α-reductase receptors in the brain, it is not known what long-term effects Dutasteride will have on the brain after taking it. Finasteride is less relevant because it specifically inhibits type 2 5α-reductase.
3. The US Food and Drug Administration (FDA) has currently allowed the use of Dutasteride in elderly people with prostate hypertrophy. Therefore, if you are over 50 years old and have hair loss problems, the use of Dutasteride (Avodart) can be considered.
4. The US FDA report mentioned that the amount of Dutasteride in the saliva or semen of men taking Dutasteride will not affect the development of the embryo. However, pregnant women must not touch the broken Dutasteride capsules to avoid absorption through the skin and causing fetal malformations.

Our Advantages

1.Quality:every item is strictly tested by our professional staff and get ISO certificate.
2.Price: much lower than our peers since we are factory. A discount would be given when you make a large order.
3.Delivery: We have adequate stock so we can make the delivery within 24 hours after payment.
4.Perfect Reshipping policy has been made to protect customers max bennefits and reduce the potentical losses.
5.Good after-sale service: always keeping track on the status of your parcel until delivered and trying our utmost to solve customers problems entounered
6.main products:Raw steroids,human growth hormone,Semi-finished oils,bodybuilding peptides,SARMs raws,Anabolic steroids