Pharmaceutical Intermediate Raw Steroid Powder Vardenafil Hydrochloride / Levitra 224785-91-5

Abstract

Vardenafil (INN) is a PDE5 inhibitor used for treating erectile dysfunction. Vardenafil's indications and contra-indications are the same as with other PDE5 inhibitors. The difference between the vardenafil molecule and is a nitrogen atom's position and the change of sildenafil's piperazine ring methyl group to an ethyl group. Tadalafil is structurally different from both and vardenafil. Vardenafil's relatively short effective time is comparable to but somewhat longer than sildenafil's.

 

Warnings

Some medicines can cause unwanted or dangerous effects when used with vardenafil. Tell your doctor about all your other medicines, especially riociguat (Adempas).

Do not take vardenafil if you are also using a nitrate drug for chest pain or heart problems, including nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and some recreational drugs such as "poppers". Taking vardenafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure.

Call your doctor or seek emergency medical attention if your erection is painful or lasts longer than 4 hours. A prolonged erection (priapism) can damage the penis.

Stop using vardenafil and get emergency medical help if you have sudden vision loss.

Before taking this medicine

Do not take vardenafil if you are also using a nitrate drug for chest pain or heart problems, including nitroglycerin, and isosorbide mononitrate. Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite ("poppers"). Taking vardenafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure.

Tell your doctor if you have ever had:

• heart disease, heart rhythm problems;

• a heart attack, stroke, or congestive heart failure;

• long QT syndrome (in you or a family member);

• high or low blood pressure;

• seizure (convulsions);

• a blood cell disorder such as sickle cell anemia, multiple myeloma, or leukemia;

• a bleeding disorder such as hemophilia;

• a stomach ulcer;

• hearing or vision problems, vision loss;

• an eye disorder such as retinitis pigmentosa (an inherited condition of the eye);

• a physical deformity of the penis (such as Peyronie's disease);

• if you have been told you should not have sexual intercourse for health reasons; or

• liver disease, kidney disease (or if you are on dialysis).

Vardenafil can decrease blood flow to the optic nerve of the eye, causing sudden vision loss. This has occurred in a small number of people, most of whom also had heart disease, diabetes, high blood pressure, high cholesterol, or certain pre-existing eye problems, and in those who smoked or were over 50 years old. It is not clear whether vardenafil is the actual cause of vision loss.

Staxyn (vardenafil disintegrating tablets) may contain phenylalanine. Talk to your doctor before using this form of vardenafil if you have phenylketonuria (PKU).

Vardenafil is not approved for use in women, and the effects of vardenafil during pregnancy or in breastfeeding women are unknown.

How should I use vardenafil?

Staxyn (vardenafil disintegrating tablets) should not be used in place of Levitra (vardenafil regular tablets). Avoid medication errors by using only the form and strength your doctor prescribes.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Vardenafil can be taken with or without food.

Remove an orally disintegrating (Staxyn) tablet from the package only when you are ready to use the medicine. Place the tablet in your mouth and allow it to dissolve without chewing. Swallow several times as the tablet dissolves. Do not swallow Staxyn with liquid.

Vardenafil is taken only when needed, about 60 minutes before sexual activity. The medicine can help achieve an erection when sexual stimulation occurs. An erection will not occur just by taking a pill.

Call your doctor or seek emergency medical attention if your erection is painful or lasts longer than 4 hours. A prolonged erection (priapism) can damage the penis.

If you receive medical care for heart problems, tell your caregivers when you last took vardenafil.

This medicine does not prevent the spread of sexually transmitted diseases such as human immunodeficiency virus (HIV).

Store at room temperature away from moisture and heat.

What should I avoid while using vardenafil?

Grapefruit and Seville oranges may interact with vardenafil and cause side effects. Avoid consuming grapefruit products and orange marmalades.

Drinking alcohol can increase certain side effects of vardenafil.

Do not use any other medicine to treat impotence unless your doctor tells you to.

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