Mesterolone / Proviron Oral Steroids Powder CAS: 1424-00-6

Proviron is very effective compound, daily dosage of 50 mg is sufficient although some men do 100 and even 250 mg/day.
Athlete normally takes one 25 mg tablet in the morning- and the other one at the evening. In some cases, even one 25mg tablet is enough.
Combo of 50 mg Proviron per day and 20 mg of Nolvadex per day results in almost complete suppression of estrogen.
 
Female usage
Women are advised not to take more than one 25 mg tablet / day. Higher doses and prolonged use for more than 4 weeks increases the risks of virilization.
Female athletes who do not have a problem with Proviron, achieve good results by taking 25 mg of Proviron per day and 20 mg of Nolvadex per day. They say that in combination with a diet it accelerates fat burning and rapid hardening of muscles

What is the development background of Proviron ?

Proviron (generic name: Mesterolone) is an oral anabolic-androgenic steroid (AAS), primarily used to treat low testosterone levels and various conditions related to male fertility. It is known for its mild anabolic (muscle-building) effects and stronger androgenic (male sex hormone-related) properties. Here's the development background of Proviron:

1. Origin and Development

Proviron was developed in 1965 by the pharmaceutical company Schering AG (now part of Bayer) in Germany. The drug was initially developed as a treatment for male infertility and low testosterone levels. The chemical structure of Mesterolone is based on dihydrotestosterone (DHT), a potent androgen that plays a significant role in the development of male characteristics.

2. Chemical Structure and Mechanism of Action

Mesterolone is a derivative of dihydrotestosterone (DHT), and its chemical structure is closely related to this natural androgen. It is a methylated version of DHT that has been modified to allow for oral administration.

Aromatase Inhibition: Proviron does not convert to estrogen, making it useful for preventing estrogenic side effects like gynecomastia (breast tissue development) that are common with many other anabolic steroids.

Androgenic Properties: Proviron has strong androgenic effects, helping to improve libido, muscle definition, and strength.

3. Medical Uses and Indications

Male Infertility: The drug was first used in the treatment of male infertility, especially in cases where low testosterone levels or impaired sperm production were the causes.

Hypogonadism: It is used in men who have low testosterone levels, as it helps increase the overall androgenic activity in the body without the risk of converting to estrogen.

Fertility Treatment: Mesterolone has been shown to help improve sperm count and motility in men with fertility issues due to low testosterone.

Proviron is not typically used as a primary testosterone replacement therapy because it does not significantly increase circulating testosterone levels, but it enhances the effects of endogenous testosterone by binding to sex hormone-binding globulin (SHBG), which allows for greater free testosterone in circulation.

4. Use in Bodybuilding and Performance Enhancement

In the bodybuilding community, Proviron is primarily used as an anti-estrogenic agent during cycles of other anabolic steroids to prevent the buildup of estrogen. By binding to SHBG, Proviron frees up more of the body's natural testosterone, which is important for enhancing muscle growth and strength.

Pre-Competition Cutting: Proviron is used to help with muscle hardness and definition in competitive bodybuilders. It is not typically used for bulk-building but for enhancing the appearance of muscle and reducing water retention.

5. Side Effects and Risks

Proviron is considered to have lower risks of side effects compared to other anabolic steroids due to its lack of aromatization (conversion to estrogen). However, like other AAS, Proviron can still cause side effects, particularly when used in high doses or over extended periods:

Androgenic Side Effects: Due to its strong androgenic properties, Proviron can cause side effects such as hair loss, acne, aggressive behavior, and enlarged prostate.

Liver Toxicity: While Proviron is less toxic to the liver compared to other oral steroids, long-term or high-dose use can still cause liver strain.

Reduced Natural Testosterone Production: As with other AAS, prolonged use of Proviron can suppress the body's natural production of testosterone.

6. Legal Status

Proviron is available by prescription in many countries, particularly for use in treating infertility and low testosterone. It is classified as a controlled substance in some countries because it is an anabolic steroid, and its use outside of medical treatment (e.g., in sports or bodybuilding) is prohibited in many regions.

7. Proviron in Modern Usage

Today, Proviron is still widely used in fertility treatments for men with low testosterone or poor sperm production. It remains a popular choice among bodybuilders during steroid cycles, especially for its ability to mitigate estrogenic effects and enhance the effectiveness of other steroids.