Safe Anti-estrogen Exemestane / Aromasin CAS: 107868-30-4 Raw Powder Supplyment

 

Specification:

 

Application:

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COA :

 

Test items	Specification	Results
Description	White crystalline powder	White powder
Identification	Positive	Positive
Assay(by hplc)	98.0~102.0%	98.64%
Absorbance(e1cm)	465~495	482.5
Melting point	191~195°c	193.5~195.0°c
Loss on drying	0.5%max	0.19%
Specific rotation	+288°~ +298°	+290.2°
Residue on ignition	0.1%max	0.03%
Related substances	Total:1.5%max	<1.3%
	Single:0.5%max	<0.4%
Residue solvents	0.2%max	0.10%
Heavy metals	20ppm max	<10ppm

Features of Aromasin

 

Aromasin (generic name: Exemestane) is an aromatase inhibitor used primarily in the treatment of hormone receptor-positive breast cancer in postmenopausal women. It works by inhibiting the enzyme aromatase, which is responsible for converting androgens (like testosterone) into estrogen. Here are the key features of Aromasin:

1. Aromatase Inhibition

Primary Mechanism: Aromasin is a steroidal aromatase inhibitor. It works by permanently binding to the aromatase enzyme, blocking its activity and reducing estrogen levels in the body. This is crucial for treating hormone receptor-positive breast cancer, where cancer cells grow in response to estrogen.

2. Postmenopausal Use

Target Population: Aromasin is specifically used in postmenopausal women for breast cancer treatment, particularly those with estrogen receptor-positive (ER-positive) tumors.

It is effective for both adjuvant (post-surgery) and advanced or metastatic breast cancer cases.

3. Estrogen Reduction

Estrogen Deprivation: By lowering estrogen levels, Aromasin can help slow the growth of certain types of breast cancer cells that rely on estrogen to thrive.

Estrogen is a key factor in the growth of many types of breast cancer, especially in postmenopausal women, making aromatase inhibitors like Aromasin an important part of hormone therapy.

4. Benefit Over Other Aromatase Inhibitors

Distinct Action: Aromasin has a unique, irreversible action on the aromatase enzyme compared to non-steroidal aromatase inhibitors like Letrozole and Anastrozole. This means that once Aromasin binds to aromatase, its effects last longer.

5. Treatment for Hormone Receptor-Positive Breast Cancer

Adjuvant Treatment: Aromasin is used after surgery (in combination with other therapies) to reduce the risk of cancer recurrence.

Metastatic Cancer: It is also used for treating advanced or metastatic hormone receptor-positive breast cancer when other treatments like tamoxifen have failed or when the cancer has progressed.

6. Usage in Men (Off-Label)

Off-Label Use: Aromasin is sometimes used in men with conditions like gynecomastia (development of breast tissue in men), as well as low testosterone.

It can help to reduce excess estrogen in men by inhibiting aromatase activity, leading to a favorable balance between estrogen and testosterone.

7. Impact on Bone Health

Bone Density: Because Aromasin reduces estrogen levels, long-term use may affect bone mineral density and increase the risk of osteoporosis.

Regular monitoring of bone health is recommended for individuals using Aromasin for extended periods.

8. Half-Life and Dosage

Half-Life: Aromasin has a long half-life of around 24 hours, allowing for once-daily administration.

Typical Dosage: The typical dosage for Aromasin in breast cancer treatment is 25 mg once per day, taken after meals.

9. Side Effects

Common Side Effects: Similar to other aromatase inhibitors, Aromasin can cause several side effects:

Hot flashes, fatigue, joint pain, and mood swings are common.

Some individuals may experience nausea, loss of appetite, and headaches.

Long-term use may cause bone thinning, osteoporosis, and increased risk of fractures.

10. Comparison with Tamoxifen

Tamoxifen vs. Aromasin: While Tamoxifen is another drug used to treat hormone receptor-positive breast cancer, Aromasin is preferred in postmenopausal women for its ability to lower estrogen levels more effectively.

Tamoxifen acts as an estrogen antagonist in breast tissue, while Aromasin works by reducing the overall production of estrogen.

 

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