Sildenafil Citrate

CAS:171599-83-0
MF:C28H38N6O11S
MW:666.7
Synonyms:, Sildenafil citrate;1-[[3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine, 2-hydroxy-1,2,3-propanetricarboxylate;1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate salt;5-[2-Ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[5,4-e]pyrimidin-7-one citrate salt;Sildenafil Citrate (100 mg);Sildenafil citrate, >=99%;Sildenafil citrate, Professional supply;5-[2-Ethoxy-5-[(4-methyl-piperazin-1-yl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one citrate
COA
| Items | Standard | Results |
| Assay by HPLC: | 98% | 99.37% |
| Appearance: | White fine powder | Complies |
| Odor & taste: | Slight bitter | Complies |
| Mesh size: | 100% pass 80mesh | Complies |
| Solubility: | Soluble in water | Complies |
| Loss on drying: | ≤2.0% | 1.15% |
| Heavy metals PPM: | <30ppm | Complies |
| Microbiology: Total Plate Count: Yeast & Mold: E.Coli: S. Aureus: Salmonella: |
<1000cfu/g <100cfu/g Negative Negative Negative |
800cfu/g 90cfu/g Complies Complies Complies |
| Conclusion: | Conform with USP 32 | |
Description
Sildenafil citrate, commonly known by the brand name Viagra, is a medication primarily used to treat erectile dysfunction (ED) in men. It belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors. These medications help enhance blood flow to the penis, aiding in achieving an erection when sexual stimulation occurs.
Erectile Dysfunction Treatment:
Sildenafil is widely prescribed to address ED, a condition where men struggle to achieve or maintain an erection firm enough for sexual activity. The drug is effective for most men, regardless of the cause of ED.
How It Works:
The medication functions by blocking the enzyme PDE5, leading to higher levels of cyclic guanosine monophosphate (cGMP). This chemical promotes relaxation in the smooth muscles of the blood vessels in the penis, allowing them to widen. As a result, more blood flows into the penis, which facilitates an erection when there is sexual arousal.
Dosage and Administration:
Sildenafil is usually taken in pill form, approximately 30 minutes to 1 hour before engaging in sexual activity. Its effects can last for a few hours, providing a time frame in which the person can be sexually active. It's essential to adhere to the prescribed dosage and follow medical guidelines for proper usage.
Effectiveness and Response:
Sildenafil has been shown to work for most individuals with erectile dysfunction, though individual responses may vary. It may not be effective for everyone, so it is crucial to consult a healthcare provider if the medication doesn't produce the desired results or if dosage adjustments are needed.
Precautions and Medical Considerations:
Before starting sildenafil, inform your doctor about any underlying medical conditions and medications you are using. Conditions such as heart disease, liver or kidney issues, or a history of priapism (a painful, prolonged erection) might require adjustments or careful monitoring. Sildenafil should not be used with nitrates, as this can lead to dangerously low blood pressure.
Side Effects:
Common side effects include headache, flushing, nasal congestion, upset stomach, and dizziness, which are typically mild and temporary. However, if you experience severe reactions or a prolonged erection lasting over four hours (priapism), seek immediate medical attention.
Dosage and Usage:
Sildenafil citrate, widely recognized under the brand name Viagra, is a medication used primarily for treating erectile dysfunction (ED) in men. It enhances blood flow to the penis, aiding in achieving and maintaining an erection. Below are key details regarding the dosage and usage of sildenafil citrate:
Usage Guidelines:
Take sildenafil citrate with a glass of water, but avoid consuming it alongside a heavy meal, as this may delay its effects.
Sildenafil citrate is effective only when there is sexual stimulation; it does not cause an automatic erection.
The medication generally takes 30 to 60 minutes to begin working, although the timing may differ for each individual.
Its effects usually last between four and six hours, but this can vary based on factors such as metabolism, overall health, and any other medications being taken.
Avoid taking sildenafil citrate if you are using nitrates (such as nitroglycerin) for chest pain or if you have specific medical conditions. Always consult your doctor or pharmacist to confirm it is suitable for you.
Before starting sildenafil citrate, it is crucial to have a discussion with your healthcare provider to review your medical history, current medications, and any potential risks or side effects.
By adhering to the recommended usage and consulting with a healthcare professional, sildenafil citrate can be used safely and effectively for managing erectile dysfunction.
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