Product Name: | Triptorelin | Pack: | Bottled |
---|---|---|---|
CAS: | 57773-63-4 | Usage: | Muscle Gaining |
Shipping Method: | EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC | Color: | White |
High Light: | pharmaceutical anabolic steroids,pharmaceutical fine chemicals |
Basic Information
Product Name | Triptorelin |
Cas No. | 57773-63-4 |
Molecular Formula | C64H82N18O13 |
Molecular Weight | 1311.46 |
Purity (HPLC) | 99% |
Appearance | White powder |
Single Impurity (HPLC) | 1.0%max |
Amino Acid Composition | ±10% of theoretical |
Peptide Content (N%) | ≥80.0% |
Water Content(Karl Fischer) | ≤6.0% |
Acetate Content (HPIC) | ≤15.0% |
MS(ESI) | Consistent |
Mass Balance | 95.0~105.0% |
Specific Rotation (20/D) | -65.0~-75.0°(c=0.5 1%HAc) |
Application
Triptorelin, a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-PRO-Gly-NH2), is a gonadotropin-releasing hormone agonist (GnRH agonist) used as the acetate or pamoate salts. By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction. Triptorelin is marketed under the brand names Decapeptyl (Ipsen) and Diphereline and Gonapeptyl (Ferring Pharmaceuticals).
What type of medication is triptorelin?
Triptorelin is a synthetic peptide analog of gonadotropin-releasing hormone (GnRH). It belongs to a class of medications known as GnRH agonists. GnRH is a hormone produced in the hypothalamus of the brain, and it plays a crucial role in regulating the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland.
Triptorelin works by binding to and stimulating the GnRH receptors in the pituitary gland initially leading to an initial surge in LH and FSH release, but with continuous administration, it ultimately downregulates these receptors, leading to a suppression of LH and FSH release. As a result, the levels of sex hormones (such as estrogen and testosterone) are decreased in both men and women.
Triptorelin is used for various medical conditions, including:
Prostate Cancer: In men with advanced prostate cancer, triptorelin is used to reduce the levels of testosterone, which can slow the growth and spread of prostate cancer cells.
Breast Cancer: In some premenopausal women with hormone receptor-positive breast cancer, triptorelin can be used to suppress estrogen production and help in the treatment of the disease.
Endometriosis: Triptorelin is sometimes used in the management of endometriosis, a condition where the tissue that normally lines the uterus grows outside it, causing pain and inflammation.
Precocious Puberty: Triptorelin can be used to delay the onset of puberty in children with certain forms of precocious (early) puberty.
Triptorelin is usually administered by injection, and the dosage and treatment schedule depend on the specific medical condition being treated. As with any medication, triptorelin may have side effects, and its use should be carefully monitored and managed by a qualified healthcare professional.
Uses
Triptorelin is used to treat advanced prostate cancer in men. It is not a cure. Most types of prostate cancer need the male hormone testosterone to grow and spread. Triptorelin works by reducing the amount of testosterone that the body makes. This effect helps slow or stop the growth of cancer cells and helps relieve symptoms such as painful/difficult urination. This medication is similar to a natural substance made by the body (luteinizing hormone releasing hormone-LHRH). Talk to your doctor about the risks and benefits of treatment.
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