Pt-141 (bremelanotide) is a highly effective α - MSH synthetic peptide analogue, which can induce estrus by stimulating melanocortin receptor. Pt-141 (bremelanotide) is composed of seven amino acids. It is a cyclic short lactam variant of α - melanocyte stimulating hormone (α - MSH). It is a multifunctional peptide that regulates many physiological functions. In this study, bremelanotide has been shown to induce lordosis in animal models and to be effective in the treatment of sexual dysfunction in men (erectile dysfunction or impotence) and women (sexual arousal disorder).
Purity: the purity of pt-141 was more than 99.0% by HPLC and MS. The peptide is synthesized without additives and is provided in the form of white lyophilized
Bremelanotide seems to stimulate libido and sexual arousal completely or mainly by activating MC4 receptor (MC3 receptor may also be involved). It regulates inflammation and limits ischemia by activating MC1 and MC4 receptors. Its potency as an erectile inducer in male rats is about 50 times that of melanin II. In animals, the treatment window (specifically, the range of sexual arousal required to induce side effects, including nausea, yawning, stretching, and loss of appetite) was greater than 1000 times, while the treatment window for Melanotan II was only 3 to 4 times. They concluded that it was more tolerable than Melanotan II.
Development of PT-141
A tanning free peptide was prepared from sun-2-141. In the initial tests, melanogen-2 did cause tanning, but in the initial 10 male volunteers, nine experienced sexual arousal and spontaneous erection.. Studies have shown that pt-141 is effective in both men (erectile dysfunction or impotence) and women (sexual arousal disorder). Unlike Viagra and other related drugs, it does not affect the vascular system, but directly increases sexual desire through the nervous system.
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