HGH 176/191(fragment) Powder

Description

HGH fragment 176-191 is a modified part of the human growth hormone (HGH) molecule. In the scientific community, it is known as "tyr-hGH177-191" and "Anti-Obesity Drug (AOD) 9604".

It has the reputation of an anti-obesity drug because it's made from the terminal part of the HGH molecule. That's the fragment that possesses specifically the fat-burning properties of the hormone.

Thus, AOD 9604 is supposed to speed up weight loss without increasing IGF-1 or insulin resistance.

Despite the fact that many sources on the internet may claim that HGH fragment 176-191 is a safe and FDA-approved peptide, the reality is that it is not sanctioned by a single government health authority in the world.

In fact, the development of this drug was terminated in 2007 due to ineffectiveness and it's never been manufactured or distributed for therapeutic use. Currently, the peptide can be used for research purposes only.

Frag 176-191 Dosage and Cycle

The limited efficacy of orally-administered human growth hormone fragment 176-191 (frag 176-191) has informed our position that frag 176-191 would be best administered via subcutaneous injection, similar to hGH.

Since frag 176-191 peptide's discontinuation for clinical evaluation, expert opinion has shifted such that an appropriate dosing range for subcutaneously injected frag 176-191 would be approximately 200-500mcg per day, for purposes of inducing weight loss in subjects.

Although frag 176-191's equivalent AOD9604 was demonstrated to have an excellent safety profile, tolerance of subcutaneous injections should still be initially assessed using conservative doses.

A hypothetical Frag 176-191 dosing protocol to help researchers understand potential study design is as follows:

Initial dose: To assess tolerance, begin with a frag 176-191 dose of 100mcg injected subcutaneously. Note that 1mg is equal to 1000mcg, and 100mcg is equal to 1/10th of a milligram.

Subsequent doses: If the initial dose is well tolerated, escalate dosing to between 200-500mcg per injection, depending on the goals of the study.

Administration timing and frequency: Based on what is understood about hGH pharmacokinetics and pharmacodynamics, frag 176-191 is likely best administered on an empty stomach, approximately 30 minutes to 1 hour prior to exercise. Note that the total daily dosage can be split between a morning and evening injection.

For intranasal formulations of frag 176-191, bioavailability will be lower due to reduced absorption of the peptide solution through the nasal membrane, compared with injection. To compensate for reduced systemic absorption, researchers could consider using the same protocol listed above, but with doses increased at each step by up to 50%.

How to Reconstitute Frag 176-191

Your injectable frag 176-191 peptide will usually arrive as a lyophilized powder in a glass vial. Lyophilization preserves the biological activity of the peptide in a temperature-stable format, allowing shipment and extended shelf-life.

To prepare frag 176-191 for injection, researchers will need to reconstitute the lyophilized peptide with bacteriostatic water. This will dissolve the powder into a clear liquid that can be drawn up into a syringe.

Prior to reconstitution, ensure that a sufficient amount of bacteriostatic water is available. Note that bacteriostatic water is recommended for reconstitution, as it will protect the peptide against contamination for at least one month due to the presence of 0.9% benzyl alcohol.

Once bacteriostatic water is on hand, determine the volume needed to dilute the peptide to the desired concentration. Refer to the following protocol on how to complete reconstitution:

Clean hands and swab the rubber stopper on the frag 176-191 vial, as well as that of the bacteriostatic water vial.

Insert the needle into the bacteriostatic water vial and draw up the required volume of water.

Remove the syringe and insert it into the frag 176-191 vial, ensuring that the full volume of bacteriostatic water is dispensed prior to removal.

Gently rotate the frag 176-191 vial until the lyophilized powder is completely dissolved.

Once the peptide is reconstituted, keep the vial refrigerated.

What are the effects of HGH Fragment 176-191?

AOD 9604 stimulates weight loss via mechanisms similar to HGH. The growth hormone stimulates the release of fatty acids from your adipose cells by triggering various cellular pathways.

Growth hormone affects the activity of several enzymes called lipases which prevent the fat from returning back into your adipose tissues.

HGH frag does not affect the natural HGH production and it does not act as a growth hormone secretagogue. It will not affect your hunger levels or increase your appetite.

Animal studies, comparing the effect of 250 mg/kg/day of AOD9604 and 1 mg/kg/day of HGH for 14 days report different results in lean and obese mice.

In lean mice, HGH but not AOD 9604 or placebo resulted in increased lean body mass. Thus it appears that HGH Fragment 176-191 is not effective in building muscle.
In obese mice, both HGH and AOD 9604 resulted in weight loss. The scientists reported a 40% reduction in adipose tissue in the HGH group vs 28% with AOD 9604.
Contrary to what most online sources may suggest, experiments reveal that HGH fragment 176-191 is less effective than HGH in burning fat.

Growth hormone likely burns more fat due to its effects on insulin resistance. It reduces glucose uptake which forces cells to take more fat instead. Unlike HGH, the fragment doesn't increase insulin resistance.

According to anecdotal evidence, AOD 9604 benefits may also include small improvements in cholesterol levels and insulin sensitivity.
Preliminary evidence from animal experiments showed that injecting the peptide into the joint may stimulate cartilage regeneration and connective tissue repair. However, human studies are lacking.

Currently, the peptide is studied for effectiveness in pain management under the name LAT 8881. However, preliminary results do not appear promising.

Does HGH Fragment really work?

Scientists found out that different parts of the HGH molecule possess different effects.

Out of all 191 amino acids, it was determined that only the last 15 amino acids are the ones mediating the fat-burning properties of the hormone. The fragment was initially named HGH 177-191 or AOD 9401.

Researchers modified the peptide by adding tyrosine to help stabilize the molecule which led to the production of a 16-amino acid fragment called AOD 9604. This made the HGH frag 176-191 more stable and orally active, unlike most other peptides.

AOD 9604 has been studied mainly in animal trials involving mice and rabbits. One of the most prominent experiments involved large oral doses of the peptide in obese Zucker rats. This led to a 50% bodyweight reduction in just 19 days.

Yet, the fragment lacks any other of HGH's effects including increasing IGF-1, insulin resistance, or cell proliferation. Thus, the compound lacks the muscle-preserving and anabolic effects of growth hormone.

Unfortunately, clinical trials with humans are extremely scarce and since the medication was discontinued, the original reports are mostly unavailable.

According to researchers who have had access to some of the data, the first randomized clinical trial with AOD 9604 reported up to 2.6 kg of weight loss in obese individuals. The participants took the peptide daily for 12 weeks in the form of oral capsules. Interestingly, lower doses were more effective.

Thus, the HGH fragment 176-191 may be able to burn fat relatively fast and produce small weight loss within 3 months.

Yet, the scientists also report that a larger study in 536 subjects failed to find any significant weight loss after 24 weeks of daily AOD 9604 use, which led to product discontinuation.

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