Follistatin 344 CAS: 80449-31-6

Description

Follistatin 344, sometimes abbreviated to "FST344", is a naturally occurring peptide in the body.

Peptides are short chains of amino acids that serve as building blocks for proteins and other hormones.

For this reason, peptides have been connected to a variety of health benefits, including gaining muscle and strength.

Follistatin 344, like many other peptides, has a unique ability to influence testosterone and other hormones essential to building lean muscle.

As such, Follistatin 344 has been utilized by weightlifters and fitness experts for decades.

Be that as it may, how the peptide was discovered actually has very little to do with building muscle.

In fact, the peptide was first discovered in the late-1980s for its role in secreting glycoprotein.

Glycoprotein is found in many tissues and organs, including the kidney, liver, and ovary.

Furthermore, glycoprotein exists in bone marrow, blood vessels, and the pituitary gland (brain).

However, in 2001, scientists found another cause for Follistatin when it was first linked with muscle growth.

Today, Follistatin 344 is readily used for men seeking to gain lean muscle and improve muscle mass.

Clinical data

Follistatin and Muscle Growth

Follistatin VialFollistatin works by binding to and inhibiting transforming growth factor (TGF) peptides such as myostatin which is responsible for regulating and limiting muscle growth. [3] It's also worth pointing out myostatin may have a regulatory role in skeletal muscle fibrosis; too much myostatin can impair tissue function and cause chronic disease in vital organs, tissues, and bone marrow.

In addition to suppressing the degenerative properties of myostatin, follistatin also suppresses the pituitary gland synthesis and secretion of follicle-stimulating hormone (FSH). [1] High FSH levels in men may indicate that testicles are not functioning correctly; this condition limits muscle growth, recovery, and normal hormonal function. However, FSH levels that are too low can also negatively impact health and reproductive capabilities.

Whereas some myostatin inhibitors like Trichostatin A (TSA) require daily administration, increased levels of FS344 were observed up to 15 months after initial injection. The lack of need for daily administration makes follistatin an attractive alternative for suppressing myostatin.

The recent increase in attention in the science community on follistatin and other myostatin inhibitors is primarily due to the desire to find an alternative means to treat muscle disorders; the most popular current option is androgen steroids which pose a number of side-effects and long-term health risks. At this point you might be wondering why follistatin use isn't more widespread in bodybuilders and other athletes.

What happens if you take follistatin?

Follistatin is a protein naturally produced by the human body, and it plays a role in regulating various biological processes, including muscle growth and development. Follistatin functions by inhibiting the activity of another protein called myostatin, which limits muscle growth. When follistatin inhibits myostatin, it can lead to increased muscle growth and potentially other effects. However, it's important to clarify that taking exogenous (external) follistatin is not a common practice, and its safety and long-term effects are not well understood. Here are some potential consequences of taking exogenous follistatin:

Increased Muscle Growth: The primary reason people might consider taking exogenous follistatin is the potential for increased muscle growth. By inhibiting myostatin, follistatin may allow for greater muscle development.

Potential for Muscle Hypertrophy: Experiments in animals and some limited studies in humans have suggested that higher levels of follistatin can lead to muscle hypertrophy, which is the increase in muscle size and mass.

Possible Effects on Fat Mass: Some studies suggest that follistatin may influence fat metabolism, potentially leading to changes in body composition, including a reduction in body fat.

Unknown Long-Term Safety: The long-term safety of taking exogenous follistatin is not well-established. Altering the natural balance of regulatory proteins like myostatin and follistatin may have unintended consequences on overall health.

Ethical and Legal Considerations: The use of exogenous follistatin for performance enhancement or aesthetic purposes may raise ethical and legal concerns.

In summary, while follistatin has a role in regulating muscle growth and development, taking exogenous follistatin for the purpose of increasing muscle mass or altering body composition is not a common or established practice. The long-term safety and potential risks associated with such use are not well-documented. Anyone considering the use of exogenous follistatin should consult with a healthcare provider and carefully consider the potential risks and ethical considerations associated with its use.

How to Use Follistatin 344

Follistatin 344 is commonly available in powder and liquid form (see, Where to Buy?).

Often, users have to reconstitute the ingredients with bacteriostatic water.

It's crucial that men follow the exact instructions provided with the packaging to ensure proper use.

Then, once the reconstituted protein is mixed, users must handle the ingredients with the right storage techniques.

Usually, this means keeping the mixture out of direct sunlight, away from extreme temperatures, and using the substance within 7-10 days.

In general, most experts suggest storing the contents in a refrigerator (even though storage at room temperature usually won't lose potency).

Next, once the peptide is ready for consumption, users have the option of injecting intravenously or subcutaneously.

Since Follistatin 344 is not regulated by the FDA there are no approved or recommended dosage guidelines.

Be that as it may, most experts suggest a general dosage between 50 – 100mcg per day.

Moreover, users should not inject Follistatin 344 for longer than 10 – 30 consecutive days.

It's also important that men follow proper cycling instructions and take a 3-4 week break before resuming the supplement.

The same is true for those seeking to stack Follistatin 344 with other muscle growth supplements.

Generally, the best advice is, to begin with a smaller dosage and witness how the body reacts.

You'll find that users are divided online as to when and how Follistatin 344 is best administered.

Regardless, it's highly advisable never to attempt and succeed 200mcg per day.

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