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Description
Gonadorelin is a medicine that is the same as gonadotropin-releasing hormone (GnRH) that is naturally released from the hypothalamus gland. GnRH causes the pituitary gland to release other hormones (luteinizing hormone [LH] and follicle-stimulating hormone [FSH]). LH and FSH control development in children and fertility in adults.
Gonadorelin is used to test how well the hypothalamus and the pituitary glands are working. It is also used to cause ovulation (release of an egg from the ovary) in women who do not have regular ovulation and menstrual periods because the hypothalamus gland does not release enough GnRH.
Gonadorelin may also be used for other conditions as determined by your doctor.
What Does Gonadotropin Do In Males?
Gonadotropins are hormones that play a crucial role in the regulation of reproductive functions in both males and females. In males, gonadotropins, specifically luteinizing hormone (LH) and follicle-stimulating hormone (FSH), have several important functions:
Stimulation of Testosterone Production: LH acts on the Leydig cells in the testes to stimulate the production of testosterone, the primary male sex hormone. Testosterone is essential for the development and maintenance of male sexual characteristics, including the growth of facial and body hair, deepening of the voice, and the development of the male reproductive organs.
Spermatogenesis: FSH plays a key role in spermatogenesis, the process by which sperm cells are produced in the testes. FSH stimulates the Sertoli cells within the testes, which, in turn, support the maturation and development of sperm cells. Without FSH, proper sperm production would not occur.
Regulation of Testicular Size: LH and FSH also help regulate the size and function of the testes. LH, through its action on Leydig cells, helps maintain testicular size and function by promoting testosterone production. FSH, through its action on Sertoli cells, supports the maturation and development of sperm within the testes.
Maintenance of Libido and Sexual Function: Testosterone, which is stimulated by gonadotropins, plays a significant role in libido (sex drive) and overall sexual function in males.
In summary, gonadotropins, specifically LH and FSH, are critical for the normal functioning of the male reproductive system. They regulate testosterone production, sperm production, and overall sexual health. Dysregulation of gonadotropin levels can lead to various reproductive health issues in males, including infertility and hormonal imbalances.
Before Using
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.Pediatric
Gonadorelin, used as a test, has been studied only in children 12 years of age and older. The medicine has not caused different side effects or problems in children 12 years of age and older than it does in adults. Children up to 12 years of age may not be sensitive to the effects of gonadorelin. Infants may be very sensitive to the effects of gonadorelin and use in infants is not recommended.Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.Drug Interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Bepridil
Cisapride
Dronedarone
Levoketoconazole
Mesoridazine
Pimozide
Piperaquine
Saquinavir
Sparfloxacin
Terfenadine
Thioridazine
Ziprasidone
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.Adagrasib
Alfuzosin
Amiodarone
Amisulpride
Amitriptyline
Anagrelide
Aripiprazole
Aripiprazole Lauroxil
Arsenic Trioxide
Asenapine
Astemizole
Atazanavir
Azithromycin
Bedaquiline
Buprenorphine
Ceritinib
Chloroquine
Chlorpromazine
Ciprofloxacin
Citalopram
Clarithromycin
Clofazimine
Clomipramine
Clothiapine
Clozapine
Crizotinib
Cyclobenzaprine
Dabrafenib
Dasatinib
Delamanid
Desipramine
Deutetrabenazine
Dexmedetomidine
Disopyramide
Dofetilide
Dolasetron
Domperidone
Donepezil
Doxepin
Droperidol
Ebastine
Efavirenz
Encorafenib
Entrectinib
Eribulin
Erythromycin
Escitalopram
Etrasimod
Famotidine
Felbamate
Fexinidazole
Fingolimod
Flecainide
Fluconazole
Fluoxetine
Formoterol
Foscarnet
Fosphenytoin
Fostemsavir
Galantamine
Gatifloxacin
Gemifloxacin
Gepirone
Glasdegib
Granisetron
Halofantrine
Haloperidol
Hydroquinidine
Hydroxychloroquine
Hydroxyzine
Ibutilide
Iloperidone
Imipramine
Inotuzumab Ozogamicin
Itraconazole
Ivabradine
Ivosidenib
Ketoconazole
Lapatinib
Lefamulin
Lenvatinib
Leuprolide
Levofloxacin
Lofexidine
Lumefantrine
Macimorelin
Mefloquine
Methadone
Metronidazole
Mifepristone
Mirtazapine
Mizolastine
Mobocertinib
Moxifloxacin
Nelfinavir
Nilotinib
Norfloxacin
Octreotide
Ofloxacin
Olanzapine
Ondansetron
Osilodrostat
Osimertinib
Oxaliplatin
Ozanimod
Pacritinib
Paliperidone
Panobinostat
Paroxetine
Pasireotide
Pazopanib
Pentamidine
Perphenazine
Phenobarbital
Pimavanserin
Pipamperone
Pitolisant
Ponesimod
Posaconazole
Primidone
Probucol
Procainamide
Prochlorperazine
Promethazine
Propafenone
Protriptyline
Quetiapine
Quinidine
Quinine
Quizartinib
Ranolazine
Relugolix
Ribociclib
Rilpivirine
Risperidone
Ritonavir
Selpercatinib
Sertindole
Sertraline
Sevoflurane
Siponimod
Sodium Phosphate
Sodium Phosphate, Dibasic
Sodium Phosphate, Monobasic
Solifenacin
Sorafenib
Sotalol
Sulpiride
Sunitinib
Tacrolimus
Tamoxifen
Telaprevir
Telavancin
Telithromycin
Tetrabenazine
Tolterodine
Toremifene
Trazodone
Triclabendazole
Trimipramine
Vandetanib
Vardenafil
Vemurafenib
Venlafaxine
Vilanterol
Vinflunine
Voclosporin
Voriconazole
Vorinostat
Zuclopenthixol
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:Gonadotropin-releasing
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