Aicar Peptide Drug Acadesine CAS 2627-69-2

Quick Details:

Product Name	AICAR
Synonym	ACADESINE;AICAR;AICA-RIBOSIDE;AMPK;5-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-BETA-RIBOSIDE;5-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-B-D-RIBOFURANOSIDE;5-AMINOIMIDAZOLE-4-CARBOXAMIDE 1-BETA-D-RIBOFURANOSIDE;Z-RIBOSIDE
CAS	2627-69-2
EINECS	220-097-5
Assay	99%
Packing	1kg net/foil bag, 5kg/drum.
Standard	Enterprise Standard
Storage	Shading , Confined Preservation
Usage	Pharmaceutical intermediates. For the treatment of cardiovascular diseases
Molecular Fomular	C9H14N4O5
Molecular Weight	258.23
Melting point	214-215 °C
Molecular Structure

COA:

What is the function of AICAR transformylase?

AICAR transformylase, also known as AICARFT (AICAR transformylase/IMP cyclohydrolase), is an enzyme involved in the purine biosynthesis pathway. It plays a crucial role in converting 5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) to Inosine monophosphate (IMP), an essential precursor for the synthesis of purine nucleotides.

AICAR transformylase catalyzes the addition of a formyl group to AICAR, resulting in the formation of N-formyl-AICAR (NFAICAR). This step is important for the subsequent reactions in the pathway.

After the transformylation step, AICAR transformylase also possesses cyclohydrolase activity. It converts NFAICAR into IMP by removing the formyl group and rearranging the molecule.

The production of IMP is a critical step in the purine biosynthesis pathway, as it serves as a precursor for the synthesis of adenine and guanine nucleotides, which are essential components of DNA, RNA, and ATP (adenosine triphosphate).

Deficiencies or dysfunctions in AICAR transformylase can lead to metabolic disorders, specifically in the purine metabolism pathway, resulting in diseases such as AICAR transformylase/IMP cyclohydrolase deficiency (ATIC deficiency). These conditions are characterized by abnormalities in the levels of purine nucleotides, leading to neurological symptoms and developmental delays.

What is the mechanism of action of AICAR?

The mechanism of action of AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) primarily involves activation of the enzyme AMP-activated protein kinase (AMPK). 

AICAR is taken up by cells and converted into its active form, ZMP (5-Aminoimidazole-4-carboxamide ribonucleotide monophosphate). ZMP mimics the effects of AMP (adenosine monophosphate), a cellular energy sensor, and allosterically activates AMPK.

Once activated, AMPK phosphorylates various downstream targets, leading to a wide range of metabolic effects. It acts as a master regulator of cellular energy homeostasis and helps maintain energy balance.

AMPK activation by AICAR has several effects on energy metabolism, including:

Enhanced glucose uptake: AMPK activation promotes the translocation of glucose transporters (such as GLUT4) to the cell surface, increasing glucose uptake by cells, particularly in skeletal muscles. This helps to increase cellular energy production.

Increased fatty acid oxidation: AICAR-activated AMPK stimulates fatty acid oxidation, allowing cells to utilize stored fats as an energy source.

Suppression of energy-consuming processes: AMPK activation inhibits energy-consuming processes such as protein synthesis, fatty acid synthesis, and cholesterol synthesis. This helps to conserve energy during times of cellular stress or energy deficit.

Mitochondrial biogenesis: AICAR-induced AMPK activation promotes the production and functioning of mitochondria, the cellular powerhouses responsible for energy production.

The activation of AMPK by AICAR leads to physiological changes similar to those seen during exercise, such as increased glucose uptake, enhanced fatty acid oxidation, and improved endurance capacity in skeletal muscles.

Any needs, please contact me

Email: amyraws195@gmail.com

Whatsapp: +86-17507125642

Telegram: +86-17507125642

Why choose us?

• Our team is dedicated to delivering the highest quality peptides with uncompromising professionalism and attention to detail.
• We do our best to carry out our duties so that we can execute more vigorously, faster and with better results.
• Our peptides are formulated to deliver the exact performance and results that you need.
• We understand that the new round of development opportunities of the enterprise, more need for the company to establish an open, competitive, incentive, efficient employment mechanism.
• Our customer service team is always available to answer any questions or concerns you may have.
• In the process of operation, we should pay attention to manufacturing quality and provide customers with satisfactory service.
• We are committed to providing our customers with customized peptides that meet their specific needs and requirements.
• We select high-quality raw materials to provide the industry with high-quality, high-stability and cost-effective Aicar Peptide Drug Acadesine CAS 2627-69-2.
• Our dedication to quality and customer satisfaction has made us a leader in the peptide industry.
• Our professional and characteristic Aicar Peptide Drug Acadesine CAS 2627-69-2 can provide you with a perfect and excellent experience.

Hot Tags: aicar peptide drug acadesine cas 2627-69-2, China aicar peptide drug acadesine cas 2627-69-2 manufacturers, suppliers, factory, Oxytocin CAS 24346 32 5, 2mg Vial Sermorelin Human Growth Peptides, Botox CAS 93384 43 1, IGF1 LR3 0 1mg ml Peptides Steroids, HGH 8x10iu STADA US Domestic, 2022 CJC1295 With DAC