PT-141, a synthetic peptide analogue of alpha-MSH, is an agonist at melanocortin receptors including the MC3R and MC4R, which are expressed primarily in the central nervous system. Administration of PT-141 to rats and nonhuman primates results in penile erections. Systemic administration of PT-141 to rats activates neurons in the hypothalamus as shown by an increase in c-Fos immunoreactivity. Neurons in the same region of the central nervous system take up pseudorabies virus injected into the corpus cavernosum of the rat penis. Administration of PT-141 to normal men and to patients with erectile dysfunction resulted in a rapid dose-dependent increase in erectile activity. The results suggest that PT-141 holds promise as a new treatment for sexual dysfunction.
Bremelanotide PT-141 is a molecule that binds to and activates the melanocortin receptors associated with skin pigmentation. Being that it
Currently, Bremelanotide PT-141 is administered via a subcutaneous injection, ideally where there are fat deposits. The only legitimate form of the peptide is injectable. Oral pills, nasal sprays, and creams have not been shown to be an effective means in which to administer Bremelanotide PT-141.
Given that everyone responds differently to Bremelanotide PT-141, effective dosages may vary. A 2mg dose is generally effective for men and women, about 1 hour prior to sexual activity. Some studies suggest starting with a 1mg test dose and injecting an identical amount 30 minutes later. By consulting your Men's Health Institute physician, you can receive a cycle protocol best suited for your condition. In studies, some subjects responded to PT-141 in minutes while others took several hours to see the effects.
Bremelanotide PT-141 is a novel treatment option for sexual dysfunction that works in both men and women.
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